Abstract
This study used CD obesity-prone (OP) and obesity-resistant (OR) rats to examine how weight gain and fat accretion relate to fermentation levels and microbiota composition after feeding resistant starch (RS). After feeding OP rats and OR rats a high-fat (HF) diet for 4 weeks, rats were stratified into three groups: they were fed either an HF diet (group 1: HF-HF) or were switched to a low-fat (LF) diet (group 2: HF-LF) or an LF diet supplemented with 20% RS by weight for 4 weeks (group 3: HF-LFRS). Energy intake, body weight, fermentation variables, and microbiota composition were determined. In OP rats, RS elicited robust fermentation (increased cecal contents, short-chain fatty acids, and serum glucagon-like peptide 1). Total bacteria, species of the Bacteroidales family S24-7, and the archaean Methanobrevibacter smithii increased. The robust fermentation did not elicit higher weight or fat accretion when compared with that of control rats fed the same isocaloric diets (HF-LF ± RS). In OR rats, body weight and fat accretion were also not different between HF-LF ± RS diets, but RS elicited minimal changes in fermentation and microbiota composition. Robust fermentation did not contribute to greater weight. Fermentation levels a...Continue Reading
References
Jun 28, 2001·Physiological Reviews·D L Topping, P M Clifton
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Jul 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruth E LeyJeffrey I Gordon
May 5, 2006·Applied and Environmental Microbiology·Alvaro BelenguerHarry J Flint
Jun 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Buck S Samuel, Jeffrey I Gordon
Oct 13, 2006·Obesity·Michael J KeenanMaren Hegsted
Apr 15, 2008·Cell Host & Microbe·Peter J TurnbaughJeffrey I Gordon
Sep 18, 2008·American Journal of Physiology. Endocrinology and Metabolism·J CachoM P Ramos
Aug 29, 2009·Journal of Agricultural and Food Chemistry·Richard T TulleyMichael J Keenan
Sep 11, 2009·Journal of Agricultural and Food Chemistry·June ZhouMichael J Keenan
Sep 18, 2009·PloS One·Bédis DridiMichel Drancourt
May 29, 2010·The Journal of Endocrinology·Andreas Nygaard MadsenNiels Vrang
May 29, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Claire Barbier de La SerreHelen E Raybould
Dec 15, 2010·PloS One·Inés MartínezJens Walter
Jun 4, 2011·Molecular Nutrition & Food Research·Li ShenRoy J Martin
Oct 27, 2012·Nutrition & Metabolism·Damien P BelobrajdicAnthony R Bird
Jan 4, 2013·PloS One·Athenia L Oldham, Kathleen E Duncan
Mar 21, 2013·Obesity·Jason A CharrierMichael J Keenan
May 1, 2013·Obesity·Kirk VidrineMichael J Keenan
May 29, 2013·Obesity·Ruchi MathurMark Pimentel
Jun 21, 2013·Obesity·Michael J KeenanReshani N Senevirathne
Jun 25, 2013·Applied and Environmental Microbiology·James J KozichPatrick D Schloss
Aug 21, 2013·Nature Methods·Robert C Edgar
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Jun 18, 2015·Expert Review of Gastroenterology & Hepatology·Ruchi Mathur, Gillian M Barlow
Nov 11, 2015·Cell Metabolism·Petia Kovatcheva-DatcharyFredrik Bäckhed
May 29, 2016·Molecular Nutrition & Food Research·Felicia GoldsmithMichael J Keenan
Jul 1, 2016·Microbiome·A VenkataramanT M Schmidt
Jul 9, 2016·Microbiome·Kate L OrmerodPhilip Hugenholtz
Nov 20, 2016·Cell·Mahesh S DesaiEric C Martens
Citations
Feb 21, 2019·Microbiome·Ilias LagkouvardosThomas Clavel
Dec 4, 2019·Molecular Nutrition & Food Research·Diana B CoulonMichael J Keenan
Jan 16, 2019·Nutrients·Elena NiccolaiAmedeo Amedei
Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Tahli Singer-EnglarRuchi Mathur
Oct 24, 2020·Nutrients·Botao WangGang Wang
Jul 30, 2020·Nutrition·Diana N ObandaMichael J Keenan
Jul 3, 2021·Frontiers in Microbiology·Anne-Lise PocheronPatricia Parnet
Dec 25, 2021·Frontiers in Nutrition·Diana N ObandaClaudia Husseneder