CD Obesity-Prone Rats, but not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight or Fat Accretion

Obesity
Diana ObandaMichael J Keenan

Abstract

This study used CD obesity-prone (OP) and obesity-resistant (OR) rats to examine how weight gain and fat accretion relate to fermentation levels and microbiota composition after feeding resistant starch (RS). After feeding OP rats and OR rats a high-fat (HF) diet for 4 weeks, rats were stratified into three groups: they were fed either an HF diet (group 1: HF-HF) or were switched to a low-fat (LF) diet (group 2: HF-LF) or an LF diet supplemented with 20% RS by weight for 4 weeks (group 3: HF-LFRS). Energy intake, body weight, fermentation variables, and microbiota composition were determined. In OP rats, RS elicited robust fermentation (increased cecal contents, short-chain fatty acids, and serum glucagon-like peptide 1). Total bacteria, species of the Bacteroidales family S24-7, and the archaean Methanobrevibacter smithii increased. The robust fermentation did not elicit higher weight or fat accretion when compared with that of control rats fed the same isocaloric diets (HF-LF ± RS). In OR rats, body weight and fat accretion were also not different between HF-LF ± RS diets, but RS elicited minimal changes in fermentation and microbiota composition. Robust fermentation did not contribute to greater weight. Fermentation levels a...Continue Reading

References

Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·Fredrik BäckhedJeffrey I Gordon
Jul 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Ruth E LeyJeffrey I Gordon
Jun 20, 2006·Proceedings of the National Academy of Sciences of the United States of America·Buck S Samuel, Jeffrey I Gordon
Sep 18, 2008·American Journal of Physiology. Endocrinology and Metabolism·J CachoM P Ramos
Aug 29, 2009·Journal of Agricultural and Food Chemistry·Richard T TulleyMichael J Keenan
Sep 11, 2009·Journal of Agricultural and Food Chemistry·June ZhouMichael J Keenan
May 29, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·Claire Barbier de La SerreHelen E Raybould
Jun 4, 2011·Molecular Nutrition & Food Research·Li ShenRoy J Martin
Oct 27, 2012·Nutrition & Metabolism·Damien P BelobrajdicAnthony R Bird
Dec 18, 2013·Nature·Lawrence A DavidPeter J Turnbaugh
Jun 18, 2015·Expert Review of Gastroenterology & Hepatology·Ruchi Mathur, Gillian M Barlow
Nov 11, 2015·Cell Metabolism·Petia Kovatcheva-DatcharyFredrik Bäckhed
May 29, 2016·Molecular Nutrition & Food Research·Felicia GoldsmithMichael J Keenan

❮ Previous
Next ❯

Citations

Feb 23, 2019·Expert Review of Gastroenterology & Hepatology·Tahli Singer-EnglarRuchi Mathur
Jul 3, 2021·Frontiers in Microbiology·Anne-Lise PocheronPatricia Parnet

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
PCR

Software Mentioned

BLAST
UPARSE

Related Concepts

Related Feeds

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Related Papers

International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity
J CoolingJ Blundell
© 2022 Meta ULC. All rights reserved