CD1-restricted T cell recognition of microbial lipoglycan antigens

Science
P A SielingP J Brennan

Abstract

It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells.

References

Apr 1, 1991·Immunological Reviews·S PorcelliH Band
Jan 1, 1991·Tissue Antigens·F Calabi, A Bradbury
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·L H MartinC Milstein
Dec 1, 1988·The Journal of Experimental Medicine·L ShiueJ R Parnes
Mar 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E L ReinherzS F Schlossman
Aug 1, 1994·The Journal of Experimental Medicine·E MichaëlssonR Holmdahl

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Citations

Jun 8, 1999·European Journal of Immunology·A ShamshievG De Libero
Oct 30, 1999·European Journal of Immunology·A MakowskaS Cardell
Sep 10, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K TsuneyamaY Nakanuma
Jan 1, 1996·International Journal of Clinical & Laboratory Research·S Romagnani
Sep 15, 2004·Immunogenetics·Fabio CastilloCarlos Parra-López
Jan 6, 2005·Springer Seminars in Immunopathology·Eric C B MilnerIñaki Sanz
Nov 29, 2007·Pflügers Archiv : European journal of physiology·David AlsteensYves F Dufrêne
Aug 1, 1996·Molecular Aspects of Medicine·M J Colston
Aug 1, 1996·Veterinary Immunology and Immunopathology·S M RhindJ Hopkins
Jul 1, 1995·Immunology Today·E M Beckman, M B Brenner
Sep 1, 1995·Research in Immunology·D J FowellR M Locksley
Jun 1, 1996·Research in Immunology·C R WangJ Deisenhofer
Jun 1, 1996·Research in Immunology·D JullienM Kronenberg
Feb 1, 1996·Trends in Microbiology·D M OjciusA Dautry-Varsat
Jan 22, 2004·Current Opinion in Immunology·Masahiko SugitaMichael B Brenner
Jan 9, 2004·International Journal for Parasitology·Diana S Hansen, Louis Schofield
Jun 1, 2005·Journal of the American Society for Mass Spectrometry·Christopher J PetzoldJulie A Leary
Oct 14, 2003·Microbes and Infection·Carme Roura-Mir, D Branch Moody
Apr 1, 1997·Journal of Comparative Pathology·C J Clarke
Aug 14, 1998·Journal of the Neurological Sciences·A Khalili-ShiraziR A Hughes
Sep 12, 1998·Primary Care·R Alam
Jun 24, 2003·Comparative Immunology, Microbiology and Infectious Diseases·Hidemi Takahashi
Mar 4, 2000·Veterinary Immunology and Immunopathology·J HopkinsS M Rhind
Apr 27, 2000·Immunology Today·G A Rook
Jun 26, 1998·Immunology Today·R M FairhurstJ Braun
Jun 26, 1998·Immunology Today·F PocciaM Malkovsky
Aug 26, 1998·Immunology Today·S A PorcelliM B Brenner
May 27, 2003·Biochimie·Jérôme NigouGermain Puzo
Jan 26, 2000·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·C BelmantJ J Fournié
Feb 2, 1999·South Dakota Journal of Medicine·J R Heins
Oct 1, 1996·Research in Immunology·R J Kurlander, C Nataraj
Oct 1, 1996·Research in Immunology·D B MoodyS A Porcelli

❮ Previous
Next ❯

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