CD10 expression in urothelial carcinoma of the bladder.

Diagnostic Pathology
Burak BahadirSukru O Ozdamar

Abstract

CD10 antigen is a 100-kDa-cell surface zinc metalloendopeptidase and it is expressed in a variety of normal and neoplastic lymphoid and nonlymphoid tissues. The aim of this study was to evaluate CD10 expression in urothelial carcinoma of the urinary bladder and to determine the correlation between immunohistochemical (IHC) CD10 expression and histopathologic parameters including grade and stage. 371 cases of urothelial bladder carcinomas, all from transurethral resections, were included in this study. Hematoxylin-eosin (HE) stained sections from each case were reevaluated histopathologically according to WHO 2004 grading system. The TNM system was used for pathologic staging. Selected slides were also studied by IHC and a semiquantitative scoring for CD10 expression based on the percentage of positive cells was performed. 157 cases (42.3%) showed immunostaining while 214 cases (57.7%) were negative for CD10. 1+ staining was seen in 65 CD10 positive cases (41.4%), and 2+ in 92 cases (58.6%). Overall CD10 expression as well as 2+ immunostaining was significantly correlated with high histologic grade. Overall CD10 expression was also significantly higher in invasive pT1 and pT2-3 tumors compared to noninvasive pTa tumors. pT1 and ...Continue Reading

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Citations

Oct 16, 2012·International Ophthalmology·Eiman Adel Hasby, Hisham Adel Saad
Jun 27, 2013·Urology Annals·Ahmed Salahaldeen MohammedMohammed Kassim Chaloob
Jan 24, 2013·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Tae Jung Jang
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Jul 10, 2012·European Journal of Gastroenterology & Hepatology·Mostafa Mohamed SiraMarwa Sabry Rizk
Aug 12, 2021·International Urology and Nephrology·Purushottam ParajuliUttam Kumar Sharma
Nov 9, 2020·European Journal of Pharmacology·Runali SankheAnoop Kishore

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