CD105 (endoglin) expression on hematopoietic stem/progenitor cells

Leukemia & Lymphoma
L PierelliG Leone

Abstract

Endoglin (CD105) is a component of the transforming growth factor-beta (TGF-beta) receptor (TGF-betaR) complex. Together with betaglycan, CD105 is considered as a TGF-betaR accessory molecule (also called TGF-betaRIII), but its functions in the receptor-ligand interactions are still poorly understood. A small subset of human CD34+ hematopoietic stem/progenitor cells that has phenotypic and functional features suggestive of very primitive hematopoietic cells expresses the CD105 antigen. CD34+/CD105+ cells recirculate in the peripheral blood of mobilized subjects and can be purified by immunomagnetic isolation strategies. The hematopoietic potential of these CD34+/CD105+ cells appears to be sustained by a combination of hematopoietic and non-hematopoietic cytokines, which comprises Flt3 ligand, erythropoietin, interleukin-15 and vascular endothelial growth factor. Endogenous TGF-beta1 is a crucial factor for the maintenance of CD34+/CD105+ immaturity acting through positive modulation of both CD105 and CD34 molecules in the absence of relevant effects on the cell cycle profile. CD105 is absent on very primitive CD34-/lineage-/CD45+ (CD34-Lin-) human hematopoietic cells isolated from cord blood. However, in vitro exposure of CD34-...Continue Reading

Citations

Jul 26, 2008·American Journal of Physiology. Renal Physiology·Baoyuan BiLloyd G Cantley
Nov 14, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Angela J ZiebarthCharles N Landen
Feb 3, 2012·European Journal of Histochemistry : EJH·C SerradifalcoV Di Felice
Jan 23, 2010·Neurological Research·Nathan ZwagermanYuchuan Ding
Apr 17, 2014·Journal of Carcinogenesis·Ravindran Kanesvaran, Min-Han Tan
Oct 11, 2014·Stem Cells International·Maiko YamamotoShinji Kuroda
Jun 18, 2010·Cellular and Molecular Life Sciences : CMLS·Stephan FrickeUlrich Sack
Jul 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yasuo MoriIrving L Weissman
Nov 10, 2009·Cytokine & Growth Factor Reviews·Misako NakashimaMasahiko Sugiyama
Jan 22, 2008·Trends in Cardiovascular Medicine·Franck Lebrin, Christine L Mummery
Jan 29, 2005·Experimental Hematology·Nathalie BoiretMarc Gabriel Berger
Feb 25, 2015·Frontiers in Immunology·Hendrik ZieglerKarin Schilbach
May 5, 2016·Cellular and Molecular Life Sciences : CMLS·Miaohua MoYaojiong Wu
Oct 2, 2004·PLoS Biology·Teresa A VeneziaMargaret A Goodell
Aug 21, 2013·American Journal of Clinical Pathology·Zaher I ChakhachiroCarlos Bueso-Ramos
Jun 17, 2011·Advances in Dental Research·M Nakashima, K Iohara
Sep 6, 2017·Cellular and Molecular Life Sciences : CMLS·Beth L Roman, Andrew P Hinck
Jul 16, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Giuseppe MoriciMaria R Bonsignore
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Takashi OnoeToshimasa Asahara
Jul 6, 2007·Journal of Neuro-oncology·Yue-Hui MaJanka Held-Feindt
Sep 1, 2017·Nature Communications·H F MoffettM T Stephan
Apr 4, 2021·International Journal of Molecular Sciences·Teresa González MuñozEnrique de Álava
Jan 30, 2004·Cytokine & Growth Factor Reviews·Mark de Caestecker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Arterial-Venous in Development & Disease

Arterial-venous development may play a crucial role in cardiovascular diseases. Here is the latest research.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.