CD105 positive neovessels are prevalent in early stage carotid lesions, and correlate with the grade in more advanced carotid and coronary plaques.

Journal of Angiogenesis Research
A LuqueJ Krupinski

Abstract

Previous studies have demonstrated that expression of CD105 is a sensitive marker and indicator of endothelial cell/microvessel activation and proliferation in aggressive solid tumour growth and atherosclerotic plaque lesions. Since intimal neovascularization contributes significantly to subsequent plaque instability, haemorrhage and rupture. We have used immunohistochemical analysis to investigate the expression of CD105-positive vessels in both large (carotid) and medium calibre (coronary and middle cerebral artery, MCAs) diseased vessels in an attempt to identify any correlation with plaque growth, stage and complication/type. Here we show, that carotid arteries expressed intimal neovascularization associated with CD105-positive endothelial cells, concomitant with increased inflammation in early stage lesions, preatheroma (I-III) whilst they were not present in coronary plaques of the same grade. Some of these CD105-positive neovessels were immature, thin walled and without smooth muscle cell coverage making them more prone to haemorrhage and rupture. In high-grade lesions, neovessel proliferation was similar in both arterial types and significantly higher numbers of CD105-positive vasa vasorum were associated with plaque re...Continue Reading

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Citations

Mar 31, 2012·Atherosclerosis·Petr NachtigalZbynek Strasky
Jul 13, 2013·Langmuir : the ACS Journal of Surfaces and Colloids·Elisabet RosàsMercedes Balcells
Oct 30, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Emi SaitaYukihiko Momiyama
Jun 5, 2014·Applied Immunohistochemistry & Molecular Morphology : AIMM·Francisco F CintraEliane M I Amstalden
Feb 11, 2014·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hala NijmehEvgenia V Gerasimovskaya
Aug 14, 2019·Journal of Atherosclerosis and Thrombosis·Qiaowei LiPengli Zhu
May 1, 2021·International Journal of Molecular Sciences·Yin LiangKen Takahashi

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