CD133(+) CD44(+) Cells Mediate in the Lung Metastasis of Osteosarcoma

Journal of Cellular Biochemistry
Aina HeYang Yao

Abstract

CD133 and CD44 are commonly used markers of cancer stem cells (CSCs), which are characterized by their ability for self-renewal and tumorigenicity. However, the clinical value and significance of CD133 and CD44 in lung metastasis of osteosarcoma (OS) remains controversial. The purpose of this study was to investigate whether CD133(+) CD44(+) cells mediates the metastasis of OS. We identified the CD133(+) CD44(+) cells in lung metastatic lesions and OS cell lines, and next demonstrated CD133(+) CD44(+) cells were more aggressive in sphere formation, migration and invasiveness compared with CD133(+) CD44(-) , CD133(-) CD44(+) , or CD133(-) CD44(-) cells. We finally sorted the CD133(+) CD44(+) and CD133(-) CD44(-) cells from Saos-2 cell lines, after intratibial xenograft in nude mice, these cells developed primary tumors, and CD133(+) CD44(+) cells are more potential to form lung metastatic tumors. Thus we concluded that CD133(+) CD44(+) cells may mediate in the lung metastasis of OS.

References

Nov 23, 1995·The New England Journal of Medicine·N BaldiniM Campanacci
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·A WeigmannW B Huttner
Jul 29, 1999·The New England Journal of Medicine·C A Arndt, W M Crist
Oct 29, 1999·Journal of Cancer Research and Clinical Oncology·M KuryuH Inoue
Feb 23, 2002·Clinical Orthopaedics and Related Research·Han-Soo KimSang Hoon Lee
Jul 22, 2004·The Oncologist·Neyssa MarinaRichard Gorlick
Oct 23, 2008·PloS One·Virginia TirinoAntonio Giordano
Apr 11, 2009·International Journal of Oncology·Hiromasa FujiiYoshinori Takakura
May 5, 2009·Stem Cells and Development·Yaojiong Wu, Philip Yuguang Wu
Mar 6, 2010·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Richard Gorlick, Chand Khanna
Mar 10, 2010·Cancer Treatment and Research·Giulia Ottaviani, Norman Jaffe
Jun 22, 2010·Journal of Pediatric Hematology/oncology·Erica BoldriniBeatriz de Camargo
Oct 15, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Ritter, S S Bielack
Mar 10, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Virginia TirinoGianpaolo Papaccio
Apr 2, 2011·Journal of Biomedical Science·Shujun LiQinghua Zhou
Nov 22, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Ana GvozdenovicBruno Fuchs
Jun 20, 2013·The Journal of Surgical Research·Jennifer SilinskyDavid A Margolin
Aug 24, 2013·BioMed Research International·Zhouming DengXiaolei Zhao
Mar 22, 2014·Molecular and Clinical Oncology·Yaoxi TanJianqing Wu

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Citations

Sep 12, 2015·Biochemical and Biophysical Research Communications·Yuekui JianXiaobin Tian
Jul 2, 2016·Stem Cells International·Ander AbarrategiRene Rodriguez
Jul 12, 2018·Journal of Cellular and Molecular Medicine·Wangdong JinThomas Efferth
Sep 22, 2017·PloS One·Amanda Dos Santos CavalcantiSuzana Assad Kahn
Feb 22, 2018·Cell Death & Disease·Zhenhua ZhouJianru Xiao
Jun 12, 2020·International Journal of Cancer. Journal International Du Cancer·Junzhi MaMonika Hartmann
Nov 20, 2016·Journal of Biomedical Science·Dong ZhangChengwei Liang

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