CD133 receptor mediated delivery of STAT3 inhibitor for simultaneous elimination of cancer cells and cancer stem cells in oral squamous cell carcinoma

Medical Hypotheses
Sai Harshini Pindiprolu, Sai Kiran S S Pindiprolu

Abstract

Oral Squamous Cell Carcinoma (OSCC) is one of the major causes of cancer related deaths worldwide. Presence of chemoresistant cancer stem cells is the major reason behind metastasis, tumor relapse and treatment resistance in OSCC. STAT 3 signalling plays a key role in survival of cancer stem cells (CSC's), Epithelial Mesenchymal Transition (EMT) mediated metastasis in OSCC. CD 133 is the surface marker for identification of cancer stem cells. In the present study we hypothesise the selective targeting of CSC's using CD 133 mediated delivery of STAT 3 inhibitor, Niclosamide to specifically target CSC's and Non CSC's.

Citations

Jul 4, 2020·Nanomedicine·Sai Kiran Ss PindiproluPavan Kumar Chintamaneni
Jan 5, 2021·Frontiers in Pharmacology·Zhilong ZhaoCongxiao Zhang
Feb 4, 2021·Acta Pharmaceutica Sinica. B·Hongxia DuanWei Huang
Feb 27, 2021·Cancer Treatment and Research Communications·Neftali VazquezMegan Keniry

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