CD138- multiple myeloma cells express high level of CHK1 which correlated to overall survival in MM patient.

Aging
Dong WuFangxia Wang

Abstract

Multiple myeloma (MM) is a disease in which abnormal plasma cells proliferate and secrete monoclonal immunoglobulin in the bone marrow. The main characteristic of plasma cells is the expression of the cell surface antigen syndecan-1 (CD138). However, the expression of CD138 is limited to terminally differentiated plasma cells during B cell development. A small subpopulation (2~5%) of human MM cells that lack CD138 expression has been shown to possess enormous proliferation potential in vitro experiment and in animal models, and they also can differentiate into CD138+ plasma cells. Thus, this small subset of MM cells was regarded as myeloma cancer stem cell (MCSC). However, its characteristics associated with the pathogenesis of MM remain unclear. In this study, we analyzed the gene expression data of CD138 cell lines downloaded from Gene Expression Omnibus (GEO) database. Limma package in RStudio was used to identify differentially expressed genes (DEGs). Genes enrichment and protein-protein interaction (PPI) network analysis were performed on DAVID and STRING databases. Furthermore, overall survival (OS) analysis in MM patient was utilized to screen out the hub-genes closely associate with the MM pathogenesis process. Hub-gene...Continue Reading

Citations

Nov 19, 2021·Frontiers in Cell and Developmental Biology·Dongsheng HeWeiming Huang

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Datasets Mentioned

BETA
GSE31305
GSE24080
GSE47552
GPL570

Software Mentioned

mSMART
one
quantity
GraphPad Prism
RStudio
StepOne
Cytoscape
Limma
DAVID
DAVID Bioinformatics Resources

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