CD138 (syndecan-1) expression in bone-forming tumors

American Journal of Clinical Pathology
Amberly L NunezShi Wei

Abstract

CD138 (syndecan-1), a cell surface proteoglycan, is sensitive and specific for plasmacytic differentiation in hematologic disorders. Expression of CD138 has been observed in a majority of epithelial neoplasms and, rarely, soft tissue tumors. However, its expression in bone tumors has not been evaluated. We studied CD138 expression in 27 osteosarcomas, 12 benign bone-forming tumors (osteoid osteoma and osteoblastoma), and 17 reactive bone cases. CD138 expression was also evaluated in a tissue microarray (TMA) constructed from 24 osteosarcomas, 24 chondrosarcomas, 12 giant cell tumors of bone, and 9 normal bone samples. Membranous expression of CD138 was found in an average of 31% of osteosarcoma cases (16/51; 14/27 [52%] in in-house cases; 2/24 [8%] in TMA cases) and in 83% of osteoid osteoma/osteoblastoma cases (10/12). Subsequent immunoglobulin κ and λ stains were negative in the CD138+ cases. All cases of chondrosarcoma, giant cell tumor of bone, and normal/reactive bone tested were nonreactive with anti-CD138. Our results show that CD138 reactivity for neoplastic cells in bone is not a definitive marker for plasmacytic origin, and caution is required to interpret CD138+ cells from a bony lesion for which a hematologic etiolo...Continue Reading

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Citations

Oct 27, 2014·Carcinogenesis·Laure-Emmanuelle ZaragosiLaurence Bianchini
Jul 9, 2016·Avicenna Journal of Medicine·Mousa A Al-AbbadiSamir S Amr
Jan 26, 2016·Applied Immunohistochemistry & Molecular Morphology : AIMM·Yihong R MaShi Wei
Sep 21, 2013·American Journal of Clinical Pathology·Thuy L NguyenShi Wei
Apr 26, 2017·Frontiers in Pharmacology·Francesco R EvolaGiuseppe Sessa
Jun 3, 2020·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Thaís Dos Santos Fontes PereiraFelipe Paiva Fonseca
Feb 27, 2021·Archives of Pathology & Laboratory Medicine·Shi Wei, Gene P Siegal

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