CD14 expression is increased on monocytes in patients with anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis and correlates with the expression of ANCA autoantigens

Clinical and Experimental Immunology
R M TarziK J Woollard

Abstract

Monocyte subsets with differing functional properties have been defined by their expression of CD14 and CD16. We investigated these subsets in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) and determined their surface expression of ANCA autoantigens. Flow cytometry was performed on blood from 14 patients with active AAV, 46 patients with AAV in remission and 21 controls. The proportion of classical (CD14(high) CD16(neg/low)), intermediate (CD14(high) CD16(high)) and non-classical (CD14(low) CD16(high)) monocytes and surface expression levels of CD14 and CD16 were determined, as well as surface expression of proteinase 3 (PR3) and myeloperoxidase (MPO) on monocyte subsets. There was no change in the proportion of monocytes in each subset in patients with AAV compared with healthy controls. The expression of CD14 on monocytes from patients with active AAV was increased, compared with patients in remission and healthy controls (P < 0.01). Patients with PR3-ANCA disease in remission also had increased monocyte expression of CD14 compared with controls (P < 0.01); however, levels in patients with MPO-ANCA disease in remission were lower than active MPO-ANCA patients, and not significantly different from contr...Continue Reading

References

Jun 1, 1992·European Journal of Immunology·A MarchantM Goldman
Jan 1, 1991·Advances in Experimental Medicine and Biology·J LüdemannW L Gross
Sep 27, 1980·British Medical Journal·A J PinchingD K Peters
Jun 12, 1999·Annals of the Rheumatic Diseases·A C Muller KoboldJ W Tervaert
Jul 12, 2005·Journal of Leukocyte Biology·Katja HattarUlf Sibelius
Sep 17, 2005·The Journal of Clinical Investigation·Adam M BoruchovJames W Young
Jan 13, 2010·Nature Reviews. Cardiology·Kevin J Woollard, Frederic Geissmann
Jul 16, 2010·Blood·Loems Ziegler-HeitbrockManfred B Lutz
Aug 18, 2010·The Journal of Clinical Investigation·Dominic J CiavattaRonald J Falk
Aug 16, 2011·Seminars in Nephrology·Ruth M TarziCharles D Pusey
Nov 15, 2011·Cell·Ivan ZanoniJonathan C Kagan
Jul 20, 2012·The New England Journal of Medicine·Paul A LyonsKenneth G C Smith
Oct 10, 2012·Arthritis and Rheumatism·J C JennetteR A Watts
Jan 26, 2013·Annual Review of Pathology·J Charles JennetteHong Xiao
Apr 4, 2013·The Journal of Clinical Investigation·Aleeza J RothRonald J Falk
Jul 31, 2013·Frontiers in Cellular and Infection Microbiology·Ivan Zanoni, Francesca Granucci
Sep 21, 2013·Nature Immunology·Luke C DaviesPhilip R Taylor
May 24, 2014·Nature Reviews. Immunology·Florent Ginhoux, Steffen Jung

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Citations

Mar 13, 2016·Autoimmunity Reviews·Pierre-André Jarrot, Gilles Kaplanski
Oct 25, 2016·Autoimmunity Reviews·Francesca BruniniCharles D Pusey
Nov 5, 2016·Current Rheumatology Reports·Luis E Vega, Luis R Espinoza
Aug 7, 2018·F1000Research·Maria Prendecki, Charles D Pusey
Jul 28, 2017·Scientific Reports·Yannick van SleenElisabeth Brouwer
Nov 28, 2019·Journal of the American Society of Nephrology : JASN·Peiqi HuJ Charles Jennette
Oct 8, 2020·International Journal of Molecular Sciences·Andreas KronbichlerJae Il Shin
Jun 11, 2021·Frontiers in Immunology·Markus ZeisbrichReinhard E Voll
Jul 24, 2021·Autoimmunity Reviews·Yosta VegtingMarc L Hilhorst

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