CD147 and Ki-67 overexpression confers poor prognosis in squamous cell carcinoma of oral tongue: a tissue microarray study

Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Yau-Hua YuNadarajah Vigneswaran

Abstract

Squamous cell carcinoma of the oral tongue (SCCOT) exhibits high risk for recurrence and regional metastasis even after surgical resection. We assessed the clinicopathologic and prognostic significance of a group of functionally related biomarkers. We used a tissue microarray consisting of SCCOT from 32 patients for this study. These patients were treated at the University of Texas MD Anderson Cancer Center from 1995 to 2008. Biomarker expression levels were examined by immunohistochemistry and graded semiquantitatively to determine their prognostic significance. CD147 and Tp63 expressions were significantly associated with a higher T stage and Ki-67 labeling index, as well as a shorter overall survival (OS) rate. Expression of Tp63 associated positively with poorly differentiated histology. There was significant association of Tp63 with the expression levels of CD147 and Glut-1. Glut-1 overexpression was marginally associated with a higher T stage. There was no prognostic significance of CD44 v6 expression in SCCOT. SCCOT with CD147 overexpression in combination with high Ki-67 labeling index had poor OS. CD147 and Ki-67 overexpression is associated with aggressive disease with poor prognosis in SCCOT.

References

Mar 1, 1992·The Clinical Investigator·H MaierH Weidauer
Oct 1, 1989·American Journal of Surgery·A R FakihA R Patel
Sep 26, 1997·Archives of Otolaryngology--head & Neck Surgery·K T PitmanE N Myers
Feb 1, 2000·International Journal of Cancer. Journal International Du Cancer·L C BordadorD M Ramos
Jul 18, 2000·International Journal of Cancer. Journal International Du Cancer·K NylanderP A Hall
Jun 8, 2001·The American Journal of Pathology·S ZuckerB P Toole
Mar 12, 2002·Archives of Otolaryngology--head & Neck Surgery·Stimson P Schantz, Guo-Pei Yu
Mar 30, 2002·Nature Biotechnology·Christoph A KleinGert Riethmüller
May 7, 2002·International Journal of Cancer. Journal International Du Cancer·Takuro KanekuraTamotsu Kanzaki
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
Aug 5, 2003·The Laryngoscope·Eben L RosenthalCandece L Gladson
Mar 5, 2004·Virchows Archiv : an International Journal of Pathology·Maria P FoschiniAnnalisa Pession
Mar 18, 2005·Cancer·Caroline H ShiboskiRichard C K Jordan
Mar 24, 2005·Cancer Metastasis Reviews·Randall H KramerHua Zhou
Jun 2, 2005·Journal of Cell Science·Kathryn D CurtinRobert J Wyman
Oct 22, 2005·Nature Reviews. Cancer·Joseph A Ludwig, John N Weinstein
Nov 29, 2005·Experimental and Molecular Pathology·Nadarajah VigneswaranWolfgang Zacharias
Dec 16, 2005·Molecular and Cellular Biology·Chonghui Cheng, Phillip A Sharp
Jan 11, 2007·Proceedings of the National Academy of Sciences of the United States of America·M E PrinceL E Ailles
Apr 19, 2007·Cancer Metastasis Reviews·Peter Vaupel, Arnulf Mayer
Sep 5, 2007·Cancer Metastasis Reviews·Daisuke Sano, Jeffrey N Myers
Oct 20, 2007·Experimental and Molecular Pathology·Kathryn T IaconoSandra J Saouaf
Apr 3, 2008·Mayo Clinic Proceedings·Shanthi Marur, Arlene A Forastiere
May 21, 2008·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Bryan P Toole, Mark G Slomiany
Jul 16, 2008·Oral Oncology·Jong-Lyel RohSang Yoon Kim
Sep 23, 2008·Oral Oncology·Saman Warnakulasuriya
Oct 15, 2008·PloS One·Brigitte Mack, Olivier Gires
Oct 16, 2008·Cellular and Molecular Life Sciences : CMLS·V Marcel, P Hainaut
Nov 18, 2008·Hematology/oncology Clinics of North America·Laura Vidal, Maura L Gillison

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Citations

Jan 19, 2016·BioMed Research International·Cory D BovenziJoseph M Curry
May 28, 2016·Cell Cycle·Susana Simões-SousaFatima Baltazar
Jul 19, 2016·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·Davide Bartolomeo GissiLucio Montebugnoli
Aug 18, 2016·Oral Oncology·Timothy J AbramJohn T McDevitt
Jun 1, 2017·Journal of Neuro-oncology·Hui LiHanwen Zhang
Jun 20, 2017·Frontiers in Oncology·Ranui BaillieTinte Itinteang
Feb 17, 2019·Virchows Archiv : an International Journal of Pathology·Alexandre Simões GarciaDenise Tostes Oliveira
Nov 1, 2020·Translational Oncology·Shilpi GuptaBhudev C Das
Mar 7, 2020·Life Sciences·Elahe TahmasebiAlexander Seifalian
Aug 28, 2021·Biomolecules·Heinrich BothaAntonio Celentano

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