CD150 association with either the SH2-containing inositol phosphatase or the SH2-containing protein tyrosine phosphatase is regulated by the adaptor protein SH2D1A

The Journal of Immunology : Official Journal of the American Association of Immunologists
L M ShlapatskaS P Sidorenko

Abstract

CD150 (SLAM/IPO-3) is a cell surface receptor that, like the B cell receptor, CD40, and CD95, can transmit positive or negative signals. CD150 can associate with the SH2-containing inositol phosphatase (SHIP), the SH2-containing protein tyrosine phosphatase (SHP-2), and the adaptor protein SH2 domain protein 1A (SH2D1A/DSHP/SAP, also called Duncan's disease SH2-protein (DSHP) or SLAM-associated protein (SAP)). Mutations in SH2D1A are found in X-linked lymphoproliferative syndrome and non-Hodgkin's lymphomas. Here we report that SH2D1A is expressed in tonsillar B cells and in some B lymphoblastoid cell lines, where CD150 coprecipitates with SH2D1A and SHIP. However, in SH2D1A-negative B cell lines, including B cell lines from X-linked lymphoproliferative syndrome patients, CD150 associates only with SHP-2. SH2D1A protein levels are up-regulated by CD40 cross-linking and down-regulated by B cell receptor ligation. Using GST-fusion proteins with single replacements of tyrosine at Y269F, Y281F, Y307F, or Y327F in the CD150 cytoplasmic tail, we found that the same phosphorylated Y281 and Y327 are essential for both SHP-2 and SHIP binding. The presence of SH2D1A facilitates binding of SHIP to CD150. Apparently, SH2D1A may function as...Continue Reading

References

Mar 5, 1992·Nature·R LüthyD Eisenberg
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·E A Clark, J A Ledbetter
Jul 20, 1995·Nature·B G CocksG Aversa
Sep 1, 1993·Protein Science : a Publication of the Protein Society·C Colovos, T O Yeates
Apr 1, 1997·Immunology and Cell Biology·G AversaJ E De Vries
Apr 1, 1997·Computer Applications in the Biosciences : CABIOS·C BarrettK Karplus
Mar 10, 1998·Cell·P HofS E Shoelson
May 23, 1998·Annual Review of Immunology·J I Healy, C C Goodnow
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·K E NicholsD A Haber
Jan 27, 1999·Bioinformatics·S R Eddy
Feb 3, 1999·Bioinformatics·K KarplusR Hughey
Jun 8, 1999·Annual Review of Immunology·E O Long
Jun 22, 1999·Current Opinion in Immunology·T Tsubata
Jun 22, 1999·Current Opinion in Immunology·J E van Leeuwen, L E Samelson
Jun 22, 1999·Current Opinion in Immunology·K S Campbell
Jul 10, 1999·Advances in Immunology·A CraxtonE A Clark
Aug 17, 1999·Current Opinion in Immunology·J L Sullivan
Sep 2, 1999·Trends in Biochemical Sciences·N GuexM C Peitsch
Sep 6, 2000·Nature·H TatsuoY Yanagi
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S G TangyeK E Nichols
Sep 15, 2000·Journal of Immunological Methods·H HamalainenR Lahesmaa

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Citations

Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A BouchonM Colonna
Feb 28, 2004·The Journal of Biological Chemistry·Patricia A ValdezIqbal S Grewal
Jan 22, 2005·Immunological Reviews·Kim E NicholsStuart G Tangye
Oct 18, 2005·Molecular and Cellular Biology·Richard V ParryJames L Riley
Jun 24, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Birgit C ViertlboeckThomas W Göbel
Nov 23, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mary E KeirArlene H Sharpe
May 25, 2006·Cell Transplantation·Wayne TruongA M James Shapiro
May 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens M ChemnitzJames L Riley
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philipp Eissmann, Carsten Watzl
Jan 12, 2007·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Elena A Ostrakhovitch, Shawn S-C Li
Jan 5, 2007·Annual Review of Immunology·Randall S Davis
Jan 5, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Megan M McCauslandShane Crotty
Jan 5, 2008·Annual Review of Immunology·Mary E KeirArlene H Sharpe
Mar 24, 2009·Proceedings of the National Academy of Sciences of the United States of America·Changlin LiJack L Strominger
Nov 17, 2009·Immunological Reviews·André VeilletteMario-Ernesto Cruz-Munoz
Apr 9, 2010·Medical Microbiology and Immunology·Elita AvotaSibylle Schneider-Schaulies
Nov 26, 2010·Annals of the New York Academy of Sciences·Cindy S Ma, Elissa K Deenick
Mar 24, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pamela M Odorizzi, E John Wherry
Mar 7, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mala Dutta, Pamela L Schwartzberg
Oct 16, 2012·Immunogenetics·Christian StraubThomas W Göbel
Jun 20, 2014·Future Oncology·Philippe Moreau, Cyrille Touzeau
Nov 21, 2019·Vaccines·Patrick O'ConnellYasser A Aldhamen
Jul 2, 2003·Journal of Leukocyte Biology·Gediminas GreiciusBernhard B Singer
Mar 26, 2005·Immunological Reviews·Mary E Keir, Arlene H Sharpe
Mar 18, 2005·Annual Review of Immunology·Rebecca J GreenwaldArlene H Sharpe
Aug 19, 2004·Blood·Svitlana V MikhalapSvetlana P Sidorenko
Jan 5, 2007·Annual Review of Immunology·Cindy S MaStuart G Tangye
Nov 18, 2003·Immunological Reviews·David M Rothstein, Mohamed H Sayegh
Apr 8, 2009·European Journal of Immunology·Jin-Sung ChungKiyoshi Ariizumi

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