PMID: 15240715Jul 9, 2004Paper

CD154 signaling regulates the Th1 response to herpes simplex virus-1 and inflammation in infected corneas

The Journal of Immunology : Official Journal of the American Association of Immunologists
Min XuR L Hendricks

Abstract

Approximately 7 days after HSV-1 corneal infection, BALB/c mice develop tissue-destructive inflammation in the cornea termed herpes stromal keratitis (HSK), as well as periocular skin lesions that are characterized by vesicles, edema, and fur loss. CD4(+) T cells and Th1 cytokines contribute to both the immunopathology in the cornea and the eradication of viral replication in the skin. We demonstrate that disruption of CD40/CD154 signaling does not impact the initial expansion of CD4(+) T cells in the draining lymph nodes, but dramatically reduces the persistence and Th1 polarization of these cells. Despite the reduced Th1 response, CD154(-/-) mice developed HSK and periocular skin disease with similar kinetics and severity (as assessed by clinical examination) as wild-type (WT) mice. However, when the composition of the inflammatory infiltrate was examined by flow cytometric analysis, CD154(-/-) mice exhibited significantly fewer CD4(+) and CD8(+) T cells and neutrophils than WT mice at the peak of HSK. Moreover, CD4(+) T cells from infected corneas of CD154(-/-) mice produced significantly less IFN-gamma than those of WT mice when stimulated with viral Ags in vitro. The IFN-gamma production of cells from infected corneas of W...Continue Reading

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Aug 9, 2002·DNA and Cell Biology·Min XuRobert L Hendricks
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Citations

Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·James P HewitsonAdrian P Mountford
May 18, 2012·Clinical & Developmental Immunology·Patrick M Stuart, Tammie L Keadle
Nov 26, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kristine-Ann G Buela, Robert L Hendricks
Dec 23, 2006·Journal of Leukocyte Biology·Andrew J LepistoRobert L Hendricks
Jun 1, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher D ConradyDaniel J J Carr

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