CD155 immunoregulation as a target for natural killer cell immunotherapy in glioblastoma.

Journal of Hematology & Oncology
Kyle B Lupo, Sandro Matosevic

Abstract

Natural killer (NK) cells are powerful immune effectors, modulating their anti-tumor function through a balance activating and inhibitor ligands on their cell surface. Though still emerging, cancer immunotherapies utilizing NK cells are proving promising as a modality for the treatment of a number of solid tumors, including glioblastoma (GBM) and other gliomas, but are often limited due to complex immunosuppression associated with the GBM tumor microenvironment which includes overexpression of inhibitory receptors on GBM cells. CD155, or poliovirus receptor (PVR), has recently emerged as a pro-tumorigenic antigen, overexpressed on GBM and contributing to increased GBM migration and aggressiveness. CD155 has also been established as an immunomodulatory receptor, able to both activate NK cells through interactions with CD226 (DNAM-1) and CD96 and inhibit them through interaction with TIGIT. However, NK cell TIGIT expression has been shown to be upregulated in cancer, establishing CD155 as a predominantly inhibitory receptor within the context of GBM and other solid tumors, and rendering it of interest as a potential target for antigen-specific NK cell-based immunotherapy. This review will explore the function of CD155 within GBM ...Continue Reading

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Citations

Feb 13, 2021·Technology in Cancer Research & Treatment·Hongpan ZhangBangXian Tan
Oct 31, 2020·Signal Transduction and Targeted Therapy·Yuqing CaoFeng Xu
Nov 24, 2020·OncoTargets and Therapy·Xianzhe YuJianguo Li
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Oct 6, 2021·Cancer Immunology, Immunotherapy : CII·Hana TrikiBoutheina Cherif

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Datasets Mentioned

BETA
AB928

Methods Mentioned

BETA
surgical resection
xenograft
xenografts

Clinical Trials Mentioned

NCT02271711
NCT03667716
NCT03712358
NCT01491893
NCT04047862
NCT03563716
NCT04256421
NCT04294810
NCT03628677
NCT04262856

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