CD18 Regulates Monocyte Hematopoiesis and Promotes Resistance to Experimental Schistosomiasis

Frontiers in Immunology
Camila O S SouzaLúcia H Faccioli

Abstract

Infection with Schistosoma mansoni causes a chronic parasitic disease that progress to severe liver and gastrointestinal damage, and eventually death. During its development into mammalian hosts, immature schistosomula transit through the lung vasculature before they reach the liver to mature into adult worms. A low grade inflammatory reaction is induced during this process. However, molecules that are required for efficient leukocyte accumulation in the lungs of S. mansoni-infected subjects are unknown. In addition, specific leukocyte subsets that mediate pulmonary response during S. mansoni migration through the lung remain to be elucidated. β2 integrins are fundamental regulators of leukocyte trans-endothelial migration and function. Therefore, we investigated their role during experimental schistosomiasis. Mice that express low levels of CD18 (the common β2 integrin subunit) and wild type C57BL/6 mice were subcutaneously infected with S. mansoni cercariae. Cellular profiles of lungs and livers were evaluated in different time points after infection by flow cytometry. Low levels of CD18 affected the accumulation of patrolling Ly6Clow, intermediate Ly6Cinter monocytes, monocyte-derived macrophages and monocyte-derived dendrit...Continue Reading

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Citations

Sep 15, 2020·Frontiers in Microbiology·Camila Oliveira Silva SouzaLúcia Helena Faccioli
Jun 11, 2020·Biomolecules·Morgana K B PradoLúcia H Faccioli
Jan 8, 2021·BMC Immunology·Tarfa AltorkiSheena Cruickshank
Apr 9, 2021·Seminars in Immunopathology·Julie SellauHannelore Lotter
Apr 20, 2021·Frontiers in Immunology·Hao SunZhichao Fan

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Methods Mentioned

BETA
dissecting
flow cytometry
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

GraphPad
Leica QWin
GraphPad Prism
FACSDiva
FlowJo
Image J

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