PMID: 7545187Jun 1, 1995Paper

CD19 and immunophenotype of bone marrow plasma cells in monoclonal gammopathy of undetermined significance

Journal of Clinical Pathology
M ZandeckiA Cosson

Abstract

To determine whether a particular phenotype or antigen is preferentially related to monoclonal gammopathies of undetermined significance (MGUS). Bone marrow specimens from 56 patients with MGUS were stained immunocytochemically (ABC peroxidase) for CD38, CD56, CD9, CD10, CD19, CD20, CD22, and MB2. Specimens from patients recently diagnosed with multiple myeloma and reactive bone marrow samples were studied in parallel. CD38 was expressed on all plasma cells from all MGUS samples tested, while 36% were positive for CD56, CD9 and MB2 were both expressed strongly; CD20 was moderately expressed, and staining for CD10 and CD22 was uncommon. For these five B cell antigens there was no clear difference between their expression in MGUS and in multiple myeloma. A great difference was found for CD19: in MGUS this antigen was expressed on 2-91% of plasma cells (mean 35%) and 77% patients had > 10% positive plasma cells; in multiple myeloma its expression was low and only 12% patients had > 10% positive plasma cells. When these results were converted to numbers of CD19 positive plasma cells per 100 nucleated bone marrow cells, reactive bone marrow and MGUS specimens had a similar number of positive plasma cells. There was no correlation be...Continue Reading

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Citations

May 24, 2005·The Journal of Dermatology·Makiko Kagaya, Hiroyuki Takahashi
Jun 10, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Jesús F San MiguelAlberto Orfao
Dec 12, 2007·Best Practice & Research. Clinical Haematology·Hervé Avet-Loiseau
Jan 8, 2000·Hematology/oncology Clinics of North America·T E Witzig
Jan 10, 2018·Cytometry. Part B, Clinical Cytometry·Sarika GuptaCarol J Holman
Sep 5, 2008·Current Protocols in Cytometry·Andy C Rawstron
Aug 3, 2020·Current Opinion in Oncology·David BeauvaisIbrahim Yakoub-Agha
Dec 22, 2016·Oncoimmunology·Djordje AtanackovicTim Luetkens
Nov 20, 2019·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Dominik F DraxlerMartin Willheim
Sep 8, 2019·Cellular Immunology·Daniel FeinbergYubin Kang

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