CD19(+)CD1d(+)CD5(+) B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses

Cellular Immunology
Mingxia ZhangXinchun Chen

Abstract

Although the importance of B cells in the host immune response upon Mycobacterium tuberculosis infection has been recognized, a conclusive role for B cells has yet to be determined. In the present study, we found that primary CD19(+) B cells isolated from patients with tuberculosis significantly inhibited Th17, but not Th1, cell activation. Moreover, the suppressive activity was mediated by a CD19(+)CD1d(+)CD5(+) B cell population. Notably, patients with tuberculosis were found to have significantly higher frequencies of CD19(+)CD1d(+)CD5(+) B cells with stronger suppressive activity than such cells from healthy donors. Furthermore, the frequency of CD19(+)CD1d(+)CD5(+) B cells in peripheral blood was inversely correlated with that of Th17 cells in patients with tuberculosis. This finding that B cells negatively regulate Th17 responses provides a novel mechanism in the regulation of CD4(+) T cell responses-aside from regulatory T cells-during M. tuberculosis infection, which may impact the clinical outcome of tuberculosis.

References

Feb 20, 2003·The Journal of Experimental Medicine·Claudia MauriMarco Londei
Dec 13, 2005·American Journal of Respiratory and Critical Care Medicine·Valerie Guyot-RevolAjit Lalvani
Dec 20, 2005·The Journal of Pathology·Timo Ulrichs, Stefan H E Kaufmann
Jan 20, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Xinchun ChenEmmanuel Katsanis
Aug 22, 2007·The Journal of Experimental Medicine·James P Scott-BrowneKevin B Urdahl
Aug 2, 2008·Microbes and Infection·Laleh MajlessiClaude Leclerc
Sep 2, 2008·Immunological Reviews·Jean-David BouazizThomas F Tedder
Sep 20, 2008·Blood·Theresa TretterHanns-Martin Lorenz
Mar 14, 2009·European Journal of Immunology·Paul J Maglione, John Chan
Mar 24, 2009·Annual Review of Immunology·Andrea M Cooper
Apr 3, 2009·Clinical and Vaccine Immunology : CVI·Xinchun ChenBoping Zhou
Nov 26, 2009·The Journal of Infectious Diseases·Subash BabuThomas B Nutman
Dec 19, 2009·American Journal of Respiratory and Critical Care Medicine·Xinchun ChenBoping Zhou
Feb 12, 2010·Annals of the New York Academy of Sciences·David J DiLilloThomas F Tedder
Feb 12, 2010·The Journal of International Medical Research·Y E WuY M Cai
Mar 13, 2010·Nature Reviews. Immunology·Frances E Lund, Troy D Randall
Apr 13, 2010·Immunological Investigations·Jesús HernandezAdriana Garibay-Escobar
Jun 16, 2010·The Journal of Experimental Medicine·Shahin ShafianiKevin B Urdahl
Jul 7, 2010·The Journal of Experimental Medicine·Hafid Ait-OufellaZiad Mallat

❮ Previous
Next ❯

Citations

Sep 29, 2015·Arthritis & Rheumatology·Athanasios MavropoulosLazaros I Sakkas
Feb 24, 2015·Immunological Reviews·Katharina RonacherTom H M Ottenhoff
Sep 27, 2015·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Martin RaoMarkus Maeurer
Dec 19, 2013·BioMed Research International·Md Murad Hossain, Mohd-Nor Norazmi
Mar 19, 2013·Cell Host & Microbe·Jacqueline M Achkar, Arturo Casadevall
Feb 25, 2015·PLoS Neglected Tropical Diseases·Guadalupe AndreaniMichel J Tremblay
May 29, 2018·Journal of Internal Medicine·S Brighenti, S A Joosten
Apr 18, 2015·BMC Immunology·Gwenoline Borhis, Yolande Richard
Jan 25, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kee Thai YeoArlene Dent
May 24, 2017·Molecular Medicine Reports·You-Chao DaiJun-Fa Xu
Jan 29, 2019·Frontiers in Immunology·Petr KonečnýMuazzam Jacobs
Sep 3, 2019·Frontiers in Immunology·Ying-Hsiu WangKuo-I Lin
Jul 22, 2018·International Journal of Molecular Sciences·Ana Esteve-SoléLaia Alsina
Aug 21, 2014·Expert Review of Respiratory Medicine·Katja ObiegloChristian Taube
Sep 15, 2020·Frontiers in Immunology·Jialing LiuXiaoyong Chen
Jun 14, 2018·International Journal of Molecular Sciences·Jorge Gallego-ValleMarjorie Pion
Jan 8, 2021·Immunological Reviews·Madhvi MenonHalima Ali Shuwa
Feb 6, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Mohammad-Javad SanaeiNader Bagheri
Mar 9, 2021·Frontiers in Immunology·Willemijn F RijninkSimone A Joosten
Mar 15, 2021·International Immunopharmacology·Miriana d'AlessandroElena Bargagli
Mar 14, 2021·Immunological Reviews·Deepshikha VermaDiane J Ordway
Mar 23, 2021·Scientific Reports·Magalí C GirardKarina A Gómez
Apr 13, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A MalkovaY Shoenfeld
Apr 13, 2021·Journal of Molecular Biology·Andre G Loxton, Ilana C van Rensburg
May 27, 2021·Trends in Immunology·Dania Zhivaki, Jonathan C Kagan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

B cell Activation

B cell activation is initiated by the ligation of the B cell receptor with antigen and ultimately results in the production of protective antibodies against potentially pathogenic invaders. Here is the latest research.