CD1d-Invariant Natural Killer T Cell-Based Cancer Immunotherapy: α-Galactosylceramide and Beyond

Frontiers in Immunology
Lisa A KingHans J van der Vliet

Abstract

CD1d-restricted invariant natural killer T (iNKT) cells are considered an attractive target for cancer immunotherapy. Upon their activation by glycolipid antigen and/or cytokines, iNKT cells can induce direct lysis of tumor cells but can also induce an antitumor immune response via their rapid production of proinflammatory cytokines that trigger the cytotoxic machinery of other components of the innate and adaptive immune system. Here, we provide an overview of various therapeutic approaches that have been evaluated or that are currently being developed and/or explored. These include administration of α-GalCer or alternative (glyco) lipid antigens, glycolipid-loaded antigen-presenting cells and liposomes, strategies that enhance CD1d expression levels or are based on ligation of CD1d, adoptive transfer of iNKT cells or chimeric antigen receptor iNKT cells, and tumor targeting of iNKT cells.

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Citations

Oct 28, 2019·Experimental & Molecular Medicine·Yingyu QinSe-Ho Park
Aug 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joshua ChoiS M Mansour Haeryfar
Oct 10, 2018·Frontiers in Immunology·Dorian StolkMark A Exley
May 31, 2019·Frontiers in Immunology·Rajkumar NoubadeKristin V Tarbell
Apr 2, 2020·Frontiers in Immunology·Yanyan LiOlivier Gasser
Jun 28, 2019·Frontiers in Immunology·Yingting ZhangWeiming Yuan
Sep 4, 2020·Chemistry and Physics of Lipids·Letícia S MartinsJulio H K Rozenfeld

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