CD1d-restricted T cell activation by nonlipidic small molecules

Proceedings of the National Academy of Sciences of the United States of America
Ildiko Van RhijnD B Moody

Abstract

In addition to NK T cells expressing invariant Valpha14 or Valpha24 T cell receptors (TCRs), the CD1d-restricted T cell repertoire is comprised of T cells with diverse TCRs that mediate inflammation during autoimmune and infectious disease. Here we describe the isolation of human Valpha24(-) T cells that are activated by antigen and CD1d. Mass spectrometric and NMR studies revealed that the stimulatory compounds were neither peptidic nor lipidic but instead were composed of sulfur and aromatic hydrocarbon rings, corresponding to the general structure of phenyl pentamethyldihydrobenzofuran sulfonates. Studies of the molecular mechanism of T cell activation showed that a clonotypic Valpha2/Vbeta21 TCR transmitted activating signals, which were highly specific for hydroxylation and methylation patterns at the terminal structures of stimulatory compounds. These studies provide evidence for noninvariant CD1d-restricted T cells in humans and identify the complete molecular structure of a nonlipidic small molecule that activates T cells through an alphabeta TCR.

References

Jul 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H KosekiM Taniguchi
Jul 14, 1995·Science·P A SielingP J Brennan
Oct 1, 1995·The Journal of Experimental Medicine·S CardellD Mathis
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·M TaniguchiY Makino
May 1, 1997·International Archives of Allergy and Immunology·W J PichlerT Wendland
Apr 7, 1998·Immunity·W A ErnstR L Modlin
Oct 23, 1998·The Journal of Experimental Medicine·F M SpadaS A Porcelli
Jan 5, 1999·The Journal of Experimental Medicine·E P GrantM B Brenner
Jun 8, 1999·European Journal of Immunology·A ShamshievG De Libero
Jun 24, 1999·The Journal of Urology·D V SteinbronnW H Carrel
Mar 14, 2000·Immunity·J E GumperzS M Behar
Aug 8, 2001·The Journal of Experimental Medicine·B WangC R Wang
Nov 15, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y N NaumovS B Wilson
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Stephan D GadolaVincenzo Cerundolo
Jun 4, 2002·Nature Medicine·Edward E S NieuwenhuisRichard S Blumberg
Jul 16, 2002·Nature Immunology·Stephan D GadolaVincenzo Cerundolo
Mar 11, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sally HuberMark Exley
Oct 11, 2003·The Journal of Biological Chemistry·Jin S ImSteven A Porcelli
Jan 24, 2004·Science·D Branch MoodyMichael B Brenner
Feb 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Thil BatuwangalaE Yvonne Jones

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Citations

Mar 29, 2008·Cancer Immunology, Immunotherapy : CII·Jay A Berzofsky, Masaki Terabe
Mar 19, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ghasem GhalamfarsaFarhad Jadidi-Niaragh
Nov 4, 1998·FEBS Letters·P EbelingV A Koivisto
Feb 9, 2010·Nature Immunology·Dale I GodfreyAlan G Baxter
Jun 4, 2013·Nature Immunology·Ildiko Van RhijnD Branch Moody
May 3, 2005·Nature Reviews. Immunology·D Branch MoodyIan A Wilson
Jun 2, 2005·Nature Reviews. Immunology·Gennaro De Libero, Lucia Mori
Mar 8, 2006·The Journal of Experimental Medicine·Stephan D GadolaE Yvonne Jones
May 27, 2009·The Journal of Experimental Medicine·Ildiko Van RhijnD Branch Moody
Aug 20, 2011·PloS One·Kambez Hajipouran BenamLing-Pei Ho
Dec 24, 2013·Nature Immunology·Annemieke de JongD Branch Moody
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Douglass WuChi-Huey Wong
May 24, 2011·Journal of Thyroid Research·Rajni B SharmaC Lynne Burek
Mar 20, 2012·Immunologic Research·Lucia Mori, Gennaro De Libero
Sep 1, 2008·Expert Review of Clinical Immunology·Nadir KadriSusanna L Cardell
May 15, 2008·Expert Opinion on Biological Therapy·Elena AmbrosinoMasaki Terabe
Jan 15, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Madhav V Dhodapkar, Joshua Richter
Dec 1, 2009·Seminars in Immunology·Dale I GodfreyJamie Rossjohn
Jun 23, 2009·Current Opinion in Immunology·Anne KasmarD Branch Moody
Jul 23, 2013·The Journal of Investigative Dermatology·Stephan RyserAngus M Moodycliffe
Oct 30, 2007·Trends in Immunology·Masaki Terabe, Jay A Berzofsky
Sep 23, 2009·Annals of the New York Academy of Sciences·Natalia Neparidze, Madhav V Dhodapkar
Jul 15, 2009·Immunological Reviews·Dirk M Zajonc, Mitchell Kronenberg
Dec 4, 2012·Clinical and Experimental Immunology·Y SimoniA Lehuen
Oct 26, 2010·Immunological Reviews·Rupali DasKim E Nichols
Jun 26, 2012·Scandinavian Journal of Immunology·S RhostS L Cardell
Oct 11, 2012·Immunological Reviews·Enrico Girardi, Dirk M Zajonc
Sep 3, 2013·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Jakob Ørskov SørensenCarl-Henrik Brogren
May 12, 2005·Current Opinion in Immunology·Ildiko Van RhijnD Branch Moody
Aug 19, 2015·Immunological Reviews·Annemieke de Jong
Aug 19, 2015·Frontiers in Immunology·Elodie Macho-Fernandez, Manfred Brigl
Nov 21, 2007·Chemistry & Biology·Annemieke de JongD Branch Moody
Oct 2, 2014·Current Opinion in Chemical Biology·Emilie LayreDavid Branch Moody
Nov 2, 2011·Respiratory Medicine·Matija RijavecPeter Korosec
Jun 21, 2016·Immunological Reviews·Vincent F VartabedianLuc Teyton
Feb 5, 2008·Immunology Letters·Lucia Mori, Gennaro De Libero
Sep 14, 2016·Trends in Immunology·Luc Van KaerSebastian Joyce
Jan 18, 2018·Cellular and Molecular Life Sciences : CMLS·Stephanie GrasJérôme Le Nours

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