PMID: 8958918Oct 31, 1996Paper

CD2-CD58 interaction and the control of T-cell interleukin-12 responsiveness. Adhesion molecules link innate and acquired immunity

Annals of the New York Academy of Sciences
J A Gollob, J Ritz

Abstract

Interleukin-12 is an antigen-presenting cell (APC)-derived cytokine that stimulates T helper cell type 1 (Th1) differentiation as well as proliferation, cytolytic activity, and IFN-gamma production among T and natural killer (NK) cells. By immunizing mice with activated T cells and screening for antibodies that could inhibit IL-12-induced proliferation, CD2 was identified as a regulator of T-cell IL-12 responsiveness. Antibodies specific for the adhesion domain of either CD2 or its primary ligand, CD58, inhibited the major functional responses of T cells to IL-12 without affecting the response to IL-2. This inhibition did not involve any alteration in IL-12 binding to T cells. The CD2-CD58 interaction between activated T cells and monocytes was found to be a critical factor in the modulation of T-cell IL-12 responsiveness, and experiments using CD58-transfected Chinese hamster ovary (CHO) cells, and stimulatory pairs of CD2 antibodies confirmed the key role of CD2 ligation in optimizing T-cell IL-12 signaling. These findings illustrate how APCs, through the differential expression of a specific adhesion molecule, can control the T-cell response to a cytokine independent of cytokine receptor expression. This has important implic...Continue Reading

References

Nov 1, 1992·The Journal of Experimental Medicine·K KatoH Yagita
Sep 1, 1995·The Journal of Experimental Medicine·J A GollobJ Ritz
Aug 1, 1995·Proceedings of the National Academy of Sciences of the United States of America·C M BaconJ J O'Shea
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Citations

Nov 14, 1997·Immunotechnology : an International Journal of Immunological Engineering·H O Sjögren
Oct 16, 2001·Drugs & Aging·S Matzku, M Zöller
Sep 6, 2014·PloS One·Jia-ning CaoSudhir Gupta
May 4, 2000·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R D AllenJ A Dobkins
May 27, 2004·The American Journal of Pathology·Philip B SugermanMarcel R M van den Brink
Nov 13, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D J LoA D Kirk
Jul 7, 2007·Neurosurgical Focus·Michelle J Clarke, Fredric B Meyer
Aug 12, 2005·Journal of Molecular Recognition : JMR·Vladimir N UverskyA Keith Dunker
Jul 11, 2006·World Journal of Gastroenterology : WJG·Li ShengMing Xie
Jun 26, 2021·Frontiers in Immunology·Yalu ZhangQuan Liao

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