PMID: 7544396Sep 1, 1995Paper

CD2 regulates responsiveness of activated T cells to interleukin 12

The Journal of Experimental Medicine
J A GollobJ Ritz

Abstract

Interleukin (IL) 12 is a 70-kD heterodimeric cytokine produced by antigen-presenting cells (APCs) such as macrophages in response to infectious pathogens and interferon (IFN) gamma. The varied immunomodulatory effects of IL-12 include the stimulation of proliferation and IFN-gamma production by T cells, and it also has a central role in the development of the T helper cell type 1 immune phenotype. We undertook the production of antibodies capable of modulating the response of T cells to IL-12, and in the process we discovered two antibodies that inhibited the ability of IL-12 to stimulate T cell proliferation. In this report, we demonstrate that these anti-bodies recognize CD2, and we show how antibodies directed toward either the adhesion domain of CD2 or its ligand, CD58, specifically inhibit IL-12 induced proliferation and IFN-gamma production by phytohemagglutinin-activated T cells, leaving the response to IL-12 unaffected. A three-to fourfold reduction in proliferation and IFN-gamma production was observed at IL-12 concentrations as high as 1 nM, with complete inhibition occurring at < or = 1 pM. This novel effect is not directly mediated at the level of the IL-12 receptor, as shown by the inability of these antibodies to ...Continue Reading

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Citations

Nov 17, 1999·Scandinavian Journal of Immunology·A C KirbyI Olsen
Apr 1, 1996·The Journal of Experimental Medicine·L BianconeI Stamenkovic
Nov 24, 1999·The Journal of Experimental Medicine·M F BachmannM Kopf
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Jun 26, 2021·Frontiers in Immunology·Yalu ZhangQuan Liao

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