CD20-negative de novo diffuse large B-cell lymphoma in HIV-negative patients: a matched case-control analysis in a single institution.

Journal of Translational Medicine
Ya-Jun LiWen-qi Jiang

Abstract

HIV-negative, CD20-negative de novo diffuse large B-cell lymphoma (DLBCL) patients has rarely been reported. To elucidate the nature of this entity, we retrospectively reviewed the data of 1,456 consecutive de novo DLBCL patients who were treated at Sun Yat-Sen University Cancer Center between January 1999 and March 2011. The pathologic characteristics of CD20-negative patients, clinical features, response to initial treatment, and outcomes of 28 patients with available clinical data (n = 21) were reviewed. Then, a matched case-control (1:3) analysis was performed to compare patients with CD20-negative and -positive DLBCL. The median age of the 28 CD20-negative DLBCL patients was 48 years, with a male-female ratio of 20:8. Seventeen of 22 (77.3%) CD20-negative DLBCL cases were of the non-germinal centre B-cell (non-GCB) subtype. High Ki67 expression (≥ 80%), an index of cell proliferation, was demonstrated in 17 of 24 (70.8%) cases. Extranodal involvement (≥ 1 site) was observed in 76.2% of the patients. Following initial therapy, 9 of 21 (42.9%) cases achieved complete remission, 4 (19%) achieved partial remission, 1 (4.8%) had stable disease, and 7 (33.3%) had disease progression. The median overall survival was 23 months. Th...Continue Reading

References

Oct 1, 1989·Pathology, Research and Practice·K TashiroK Ohshima
Jan 1, 1994·Journal of Clinical Pathology·L A NoorduynC J Meijer
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN International Non-Hodgkin's Lymphoma Prognostic Factors Project
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J O Armitage, D D Weisenburger
Nov 12, 1998·The American Journal of Pathology·A ChottH K Müller-Hermelink
May 29, 2004·The American Journal of Surgical Pathology·Lluís ColomoElías Campo
Nov 3, 2004·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J Teruya-FeldsteinA Noy
May 4, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·P FeugierB Coiffier
Aug 11, 2005·Current Oncology Reports·Julie Teruya-Feldstein
Jun 7, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas M HabermannSandra J Horning
Feb 6, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Kaaren K ReichardSteven H Kroft
Jan 30, 2008·The Lancet Oncology·Michael PfreundschuhUNKNOWN German High-Grade Non-Hodgkin Lymphoma Study Group (DSHNHL)
Apr 23, 2009·American Journal of Hematology·Adi BroydeOsnat Bairey
Jul 29, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Camille LaurentPierre Brousset
Oct 13, 2009·Blood Cells, Molecules & Diseases·Xiaoyan KeXiao-Feng Yang
Jan 19, 2010·MAbs·Ezogelin Oflazoglu, Laurent P Audoly
Mar 31, 2010·Seminars in Hematology·Stephen A BeersMartin J Glennie
Apr 7, 2010·Leukemia & Lymphoma·Myron S Czuczman, Stephanie A Gregory
Nov 5, 2010·The New England Journal of Medicine·Anas YounesAndres Forero-Torres
Mar 15, 2011·Expert Opinion on Biological Therapy·Sam MayesTim M Illidge
Apr 14, 2011·Diagnostic Pathology·Veronika Kloboves PrevodnikBarbara Jezeršek Novakovič
Sep 29, 2011·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Jamie D Croxtall
Mar 29, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anas YounesRobert Chen
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara ProAndrei Shustov

❮ Previous
Next ❯

Citations

Jul 22, 2014·British Journal of Haematology·Shoko NakayamaToshiaki Hanafusa
Apr 23, 2014·International Journal of Laboratory Hematology·K Hebeda, F Preijers
Jan 3, 2015·Archives of Pathology & Laboratory Medicine·Dennis P O'MalleyLawrence M Weiss
Feb 2, 2017·Diagnostic Pathology·Shin-Ichi NakatsukaEiichi Morii
Oct 7, 2017·International Journal of Surgical Pathology·Badr AbdullGaffar, Rania M Seliem
Jul 4, 2018·International Journal of Surgical Pathology·Amy StarrBhaskar Kallakury
Oct 17, 2014·Journal of Clinical and Experimental Hematopathology : JCEH·Rie TabataMasaru Kojima
Feb 3, 2015·Expert Review of Hematology·Jorge J CastilloSantiago Montes-Moreno
Jun 9, 2016·Advances in Anatomic Pathology·Penelope KorkolopoulouMaria Ioannou

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbent assay
surgical resection

Software Mentioned

SPSS

Related Concepts

Related Feeds

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.