PMID: 7524302Oct 1, 1994Paper

CD20+ T-cell lymphoma. Neoplastic transformation of a normal T-cell subset

American Journal of Clinical Pathology
L Quintanilla-MartínezN L Harris

Abstract

CD20 is a 35-kDa protein that is expressed early in B-cell ontogeny and is lost during terminal B-cell differentiation into plasma cells. It is thought to be B-cell-specific. However, the CD20 antigen, detected by the monoclonal antibody L26, has been reported in some cases of T-cell lymphoma. This report describes a case of a malignant lymphoma coexpressing T-cell-lineage antigens and CD20 and characterization of a CD20+ T-cell population in the peripheral blood of healthy donors. The tumor cells were pleomorphic medium-sized cells that expressed a range of T-cell-specific antigens, including CD2, CD3, CD4, CD5, CD6, CD7, and beta F1. In addition, the tumor cells expressed CD20 on frozen (B1) and paraffin sections (L-26). Stains for other pan-B cell antigens, including CD19 and CD22, and immunoglobulin light and heavy chains were negative. To determine whether this unusual coexpression of T-cell-lineage antigens and CD20 represented aberrant antigen expression or neoplastic transformation of an unusual normal T-cell subset, the authors examined specimens of peripheral blood lymphocytes from healthy donors for evidence of a CD20+ T-cell population by using three-color immunofluorescence analysis by flow cytometry. Two distinct ...Continue Reading

Citations

Jun 1, 1996·The American Journal of Surgical Pathology·N MoriJ Asai
Jul 17, 1999·Journal of Cutaneous Pathology·C ChaiV G Prieto
Jun 11, 2005·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·A B SoaresM L Cintra
Apr 26, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Philip WentStefano A Pileri
Jan 26, 2007·Virchows Archiv : an International Journal of Pathology·J GoninJ Audouin
Aug 2, 2008·Cytometry. Part B, Clinical Cytometry·Kathryn RizzoConstance M Yuan
Aug 19, 2009·Internal Medicine·Koji MiyazakiMasaaki Higashihara
Jan 9, 2010·Histopathology·Alistair Robson
Aug 17, 2012·The American Journal of Surgical Pathology·Jennifer L OliveiraAndrew L Feldman
Oct 4, 2018·Veterinary Pathology·Isao MatsumotoKazuyuki Uchida
Oct 31, 2001·Immunology·G Grafton, L Thwaite
Apr 22, 2003·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Birte SteinigerPeter J Barth
May 19, 2007·American Journal of Clinical Pathology·Robert P Hasserjian, Nancy Lee Harris
Feb 12, 2008·Journal of Cutaneous Pathology·Filiz SenKenneth Hymes
Feb 1, 2006·Arthritis and Rheumatism·Maria J LeandroJonathan C W Edwards
Jul 20, 2007·European Journal of Haematology·Markus HanssonMichael Dictor
Jun 1, 2011·Journal of Cutaneous Pathology·Blanca MartinAlistair Robson
Sep 17, 2011·Leukemia & Lymphoma·Periklis G FoukasIoannis G Panayiotides
Feb 26, 2009·The British Journal of Dermatology·H OshimaD Sawamura
Jun 15, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jacquelyn M LykkenThomas F Tedder
Jan 19, 2018·Veterinary Pathology·Erica L Noland, Matti Kiupel
Oct 12, 2018·BMC Veterinary Research·Mathieu V PaulinValérie Freiche
Nov 5, 2019·Cytometry. Part B, Clinical Cytometry·Yan-Li LiZhi-Min Zhai
Apr 22, 2020·Virchows Archiv : an International Journal of Pathology·Yuhua HuangJingping Yun
Jul 11, 2001·Advances in Anatomic Pathology·E D Hsi, S Yegappan
Dec 6, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·R L Mohrmann, D A Arber
Mar 10, 2001·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·X YaoE S Jaffe
Dec 7, 2007·International Journal of Hematology·Sonoko Nakano-AkamatsuTohru Inaba
Nov 18, 2008·The American Journal of Surgical Pathology·Jun WangQin Huang
Feb 2, 2010·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrew L FeldmanWilliam R Macon
Mar 26, 2009·The American Journal of Dermatopathology·Nicole N BalmerAleodor A Andea
Dec 8, 2011·Annals of Dermatology·Ki Yeol LeeKi Ho Kim
Dec 17, 2016·Journal of Clinical and Experimental Hematopathology : JCEH·Riko KawanoKoichi Ohshima
Nov 16, 2018·Pediatric Rheumatology Online Journal·Courtney B CrayneRandy Quentin Cron
Jul 27, 2000·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·K BlakolmerA Chott
Jun 28, 2001·American Journal of Hematology·M YasukawaS Fujita
Aug 30, 2008·Journal of Clinical Pathology·C AgostinelliS A Pileri
Sep 8, 2010·The Journal of International Medical Research·W-B XiaoL-J Wang

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