CD22 regulates time course of both B cell division and antibody response

The Journal of Immunology : Official Journal of the American Association of Immunologists
Taishi OnoderaTakeshi Tsubata

Abstract

Because pathogens induce infectious symptoms in a time-dependent manner, a rapid immune response is beneficial for defending hosts from pathogens, especially those inducing acute infectious diseases. However, it is largely unknown how the time course of immune responses is regulated. In this study, we demonstrate that B cells deficient in the inhibitory coreceptor CD22 undergo accelerated cell division after Ag stimulation, resulting in rapid generation of plasma cells and Ab production. This finding indicates that CD22 regulates the time course of B cell responses and suggests that CD22 is a good target to shorten the time required for Ab production, thereby augmenting host defense against acute infectious diseases as "universal vaccination."

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Citations

Dec 17, 2008·Annals of the New York Academy of Sciences·Stephan von Gunten, Bruce S Bochner
Oct 4, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kyle J BednarMatthew S Macauley
Oct 17, 2018·Frontiers in Immunology·Edward A Clark, Natalia V Giltiay
Jul 15, 2009·Immunological Reviews·Lars Nitschke
Oct 23, 2012·International Reviews of Immunology·Thomas DörnerKenneth G C Smith
Jul 10, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jennifer MüllerLars Nitschke
May 29, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yinan JiangXun Cai
May 21, 2014·PloS One·Edmund A RossiDavid M Goldenberg
Apr 26, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Miduo XuTakeshi Tsubata
Jan 19, 2021·Clinical and Experimental Immunology·H Rincón-ArévaloD Castaño
Aug 1, 2021·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sarah J MeyerLars Nitschke

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