CD24 Ala/Val polymorphism and multiple sclerosis.

Journal of Neuroimmunology
An GorisS J Sawcer

Abstract

CD24 is expressed on a broad range of cells in the immune and central nervous systems and appears to be required for development of experimental autoimmune encephalomyelitis in mice. Association of a CD24 Ala/Val coding polymorphism with susceptibility to and progression of multiple sclerosis was recently reported. We typed this coding polymorphism in a combined cohort of 1,180 cases and 1,168 unrelated and family-based controls from Belgium and the UK, but were unable to confirm either association. Since the CD24 gene is part of a segmental duplication, special care is required for the identification and genotyping of single nucleotide polymorphisms.

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Dec 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·Qunmin ZhouYang Liu
Jul 13, 2004·Nature Genetics·David FredmanAnthony J Brookes
Aug 5, 2005·American Journal of Human Genetics·Stephen SawcerUNKNOWN International Multiple Sclerosis Genetics Consortium

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Citations

Feb 16, 2010·Cellular & Molecular Immunology·Xianfeng FangYang Liu
Mar 17, 2009·Biological Chemistry·Christina BleckmannRudolf Geyer
Aug 6, 2011·The International Journal of Neuroscience·Abolghasem KollaeeMahdi Zamani
Jun 4, 2015·International Journal of Molecular Sciences·Georgia G BraliouPantelis G Bagos
Jun 21, 2011·Human Immunology·Lina-Marcela Diaz-GalloJavier Martin
Jul 18, 2008·Journal of Neuroimmunology·Sreeram V RamagopalanGeorge C Ebers
May 29, 2007·Trends in Immunology·Yang Liu, Pan Zheng
Jul 19, 2015·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Ilana KaplanSarah Kraus
Aug 8, 2015·Computers in Biology and Medicine·Jihae BaekHyeyoung Min
Sep 1, 2007·Arthritis and Rheumatism·Elena SánchezJavier Martín
Sep 18, 2007·Expert Review of Neurotherapeutics·Masaaki NiinoHidenao Sasaki
Apr 25, 2020·Scandinavian Journal of Gastroenterology·Chengcheng Christine ZhangChristian Rupp
Feb 24, 2016·World Journal of Gastroenterology : WJG·Zhi-Fang JiaJing Jiang
Feb 22, 2014·The International Journal of Biological Markers·Victoria LisianskyMenachem Moshkowitz
May 29, 2015·World Journal of Gastroenterology : WJG·Xiao-Li HuangCheng-Gong Yu
Feb 11, 2021·Journal of Personalized Medicine·Keren NitzanRavid Doron

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