CD24 expression as a marker for predicting clinical outcome and invasive activity in uterine cervical cancer

Oncology Reports
Tomohito TanakaMasahide Ohmichi

Abstract

CD24, a small heavily glycosylated mucin-like glycosyl-phosphatidylinositol-anchored cell surface protein, plays an important role in the carcinogenesis of various human malignancies. However, its function in cervical cancer remains unclear. The aim of the present study was to evaluate the expression of CD24 clinicopathologically and to analyze its functional behavior biologically in cervical cancer. A total of 117 uterine cervical cancer tumors were immunohistochemically analyzed using a CD24 monoclonal antibody on paraffin blocks. We also examined whether CD24 enhanced the invasive activity or the Akt, ERK, NF-κB and MMP activity in a uterine cervical cancer cell line (CaSki) by a western blot analysis. The patients with enhanced CD24 expression had a higher rate of advanced clinical stage (50 vs. 16.5%, p<0.01), lymph node metastasis (34.6 vs. 14.3%) and lymphovascular involvement (65.4 vs. 20.4%, p=0.01), and a poor overall and disease-free survival (5-year survival rate: 62 vs. 86%, p=0.03). CD24 overexpression in CaSki cells resulted in activation of Cell Signaling proteins, including Akt, ERK, NF-κB and MMP-9. An invasion assay showed that CD24 overexpression in CaSki cells led to increased invasion ability. The CD24 ove...Continue Reading

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Citations

Aug 14, 2020·International Journal of Cancer. Journal International Du Cancer·Peter AltevogtGlen Kristiansen
Oct 16, 2016·Pathology Oncology Research : POR·Deniz ArikÖzgül Paşaoğlu
Sep 18, 2017·Updates in Surgery·Gaetano ValentiAntonio Simone Laganà
Nov 3, 2017·Cancer Science·Hinako OkabeKiyotsugu Yoshida
Jun 25, 2020·Current Gene Therapy·Yang-Hong NiWei Wang
Dec 11, 2020·Cell Death Discovery·Sivasundaram KarnanYoshitaka Hosokawa
Oct 1, 2021·Pathology Oncology Research : POR·Muhammad Ihtisham UmarXianju Huang

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Methods Mentioned

BETA
hysterectomy
PCR
transfection
electrophoresis
scraping

Software Mentioned

JMP

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