CD25 and indoleamine 2,3-dioxygenase are up-regulated by prostaglandin E2 and expressed by tumor-associated dendritic cells in vivo: additional mechanisms of T-cell inhibition

Blood
Michael S von Bergwelt-BaildonJoachim L Schultze

Abstract

Immune tolerance is a central mechanism counteracting tumor-specific immunity and preventing effective anticancer immunotherapy. Induction of tolerance requires a specific environment in which tolerogenic dendritic cells (DCs) play an essential role deviating the immune response away from effective immunity. It was recently shown that maturation of DCs in the presence of PGE2 results in upregulation of indoleamine 2,3-dioxygenase (IDO) providing a potential mechanism for the development of DC-mediated Tcell tolerance. Here, we extend these findings, demonstrating a concomitant induction of IDO and secretion of soluble CD25 after DC maturation in the presence of PGE2. While maturation of DCs induced IDO expression on transcriptional level, only integration of PGE2 signaling led to up-regulation of functional IDO protein as well as significant expression of cell-surface and soluble CD25 protein. As a consequence, T-cell proliferation and cytokine production were significantly inhibited, which was mediated mainly by IDO-induced tryptophan depletion. Of importance, we demonstrate that different carcinoma entities associated with elevated levels of PGE2 coexpress CD25 and IDO in peritumoral dendritic cells, suggesting that PGE2 migh...Continue Reading

References

Jan 1, 1986·Annual Review of Biochemistry·P NeedlemanJ B Lefkowith
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·J L SchultzeL M Nadler
Nov 14, 1997·International Journal of Cancer. Journal International Du Cancer·A H EnkJ Knop
Oct 28, 1998·Journal of the National Cancer Institute·M M Taketo
May 4, 1999·The Journal of Experimental Medicine·D H MunnA L Mellor
Sep 29, 1999·Immunology Today·A L Mellor, D H Munn
Feb 29, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K SatoT A Takahashi
Mar 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·P HwuH A Young
Jun 7, 2000·The Journal of Clinical Investigation·C S WilliamsR N DuBois
Jul 21, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·U GrohmannP Puccetti
Nov 22, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A DzionekJ Schmitz
Mar 30, 2001·The Journal of Biological Chemistry·C H LiuT Hla
Dec 26, 2001·International Immunology·Francesca FallarinoPaolo Puccetti
Feb 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Hedi HariziNorbert Gualde
Feb 28, 2002·Trends in Immunology·Sarah G HarrisRichard P Phipps
Mar 22, 2002·The Lancet Oncology·A J DannenbergK Subbaramaiah
Apr 9, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Andrew L MellorDavid H Munn
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dagmar von BubnoffThomas Bieber
Mar 5, 2003·Annual Review of Immunology·Drew Pardoll
Mar 6, 2003·The Journal of Clinical Investigation·Li YangRichard M Breyer
Mar 23, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·David H MunnAndrew L Mellor
Jul 9, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jens M ChemnitzJames L Riley
Jul 16, 2004·The Journal of Clinical Investigation·David H MunnAndrew L Mellor
Sep 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuharu AkasakiJohn S Yu
Oct 2, 2004·Nature Reviews. Immunology·Andrew L Mellor, David H Munn

❮ Previous
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Citations

Oct 6, 2010·Archivum Immunologiae Et Therapiae Experimentalis·Jacek R Wilczyński, Markus Duechler
Sep 19, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Alexey Popov, Joachim L Schultze
Dec 30, 2006·Cancer Immunology, Immunotherapy : CII·Marion WobserJuergen C Becker
Jan 4, 2012·Cancer Immunology, Immunotherapy : CII·Sofia EberstålPeter Siesjö
Apr 29, 2008·Journal of Cancer Research and Clinical Oncology·Ke PanJian-chuan Xia
Feb 20, 2010·Nature Reviews. Cancer·Dingzhi Wang, Raymond N Dubois
Feb 22, 2012·Nature Reviews. Immunology·Onur Boyman, Jonathan Sprent
Oct 7, 2008·Oncogene·N ChaputL Zitvogel
Jan 9, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hans J KuengWinfried F Pickl
Nov 26, 2013·The Cancer Journal·Dingzhi Wang, Raymond N DuBois
Nov 30, 2006·Annual Review of Immunology·Ann M LeenAaron E Foster
May 4, 2007·The Journal of Clinical Investigation·David H Munn, Andrew L Mellor
Aug 22, 2009·Journal of Translational Medicine·Yan-Fang GaoXiao-Shi Zhang
Oct 2, 2014·The Journal of Clinical Investigation·Fumihiro OgawaMasataka Majima
Sep 29, 2012·Immunological Investigations·Theodore S Johnson, David H Munn
Sep 29, 2012·Immunological Investigations·Nataša ObermajerPawel Kalinski
Apr 7, 2010·International Reviews of Immunology·Lei HuangAndrew L Mellor
Apr 14, 2015·Seminars in Cancer Biology·Stephanie C CaseyDean W Felsher
Jan 27, 2010·Expert Opinion on Therapeutic Patents·Tiziana Di PucchioSergio Rutella
Jun 19, 2009·Expert Opinion on Therapeutic Targets·P H Tan, A K Bharath
Sep 5, 2008·Expert Review of Vaccines·M DauerA Eigler
Oct 13, 2007·Expert Review of Vaccines·Michael von Bergwelt-Baildon
Aug 25, 2015·Translational Research : the Journal of Laboratory and Clinical Medicine·Srikanth SanthanamMatthew A Ciorba
Mar 5, 2013·Cellular Immunology·Alexander Shimabukuro-VornhagenMichael S von Bergwelt-Baildon
May 27, 2015·Immunology and Cell Biology·Kristian M HargadonOsric A Forrest
May 12, 2011·Drug Discovery Today·Monireh Torabi-RahvarAmir Hassan Zarnani
May 17, 2011·Cellular Immunology·Antonio CiaramellaPaola Bossù
May 19, 2009·Seminars in Immunology·Jinguo WangPere Santamaria
May 12, 2009·Peptides·Kate H EastenJulie D McLeod
Oct 18, 2008·Immunobiology·Julia DriesenJoachim L Schultze
Oct 1, 2008·Immunology Letters·Hui XuAbdolmohamad Rostami

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