CD25+CD4+ T cells in human cord blood: an immunoregulatory subset with naive phenotype and specific expression of forkhead box p3 (Foxp3) gene

Experimental Hematology
Yasushi TakahataToshiro Hara

Abstract

To address the role of cord blood (CB) CD25+CD4+ T cells, the gene expressions and function of this subset were analyzed. CD25+CD4+ T cells fractionated from CB of term and preterm infants were subjected to flow cytometry, quantitative polymerase chain reaction analysis for cytokines, costimulatory molecules, and transcription factors, and functional assays. Human preterm CB contained a high proportion of CD25+CD4+ T cells that declined with gestational age to the level of adult peripheral blood (PB). CD25+ or CD25-CD4+ T cells in CB had a higher frequency of CD45RA+ and CD38+ cells than in PB. CB CD25+CD4+ T cells less frequently expressed CD45RO, CD71, and HLA-DR than PB CD25+CD4+ T cells, despite similar expressions on CB and PB CD25-CD4+ T cells. No expression of IL-10, transforming growth factor-beta, interleukin-4, and interferon-gamma mRNA differed between CB CD25+CD4+ and CD25-CD4+ T cells, in contrast to the high interleukin-10 expression in PB CD25+CD4+ T cells. CTLA-4 was more transcribed in CB and PB CD25+CD4+ T cells than in the counterpart CD25-CD4+ T cells. CD28 or ICOS was similarly expressed in CB and PB T cells. CB CD25+CD4+ T cells effectively suppressed the proliferation of CB CD25-CD4+ T cells in a dose-dep...Continue Reading

References

Sep 22, 1977·Nature·M B OldstoneL Moretta
Mar 14, 1995·Proceedings of the National Academy of Sciences of the United States of America·G RisdonH E Broxmeyer
Aug 11, 1998·Clinical and Experimental Immunology·S HodgeP Han
Oct 3, 1998·Human Immunology·H ZolaP J Macardle
Jun 11, 1999·Human Immunology·S B CohenJ A Madrigal
Jun 24, 1999·Immunology Today·B Adkins
Nov 28, 2001·Immunological Reviews·E H FieldQ Gao
Jun 6, 2002·Immunology·Kajsa WingElisabeth Suri-Payer
Jan 11, 2003·Science·Shohei HoriShimon Sakaguchi
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Mar 4, 2003·Nature Immunology·Roli KhattriFred Ramsdell

❮ Previous
Next ❯

Citations

Nov 4, 2008·Clinical and Experimental Medicine·Nadereh NaderiSeyed Mohammad Moazzeni
Dec 3, 2011·Clinical Reviews in Allergy & Immunology·Syh-Jae LinMing-Ling Kuo
Dec 4, 2010·Immunologic Research·Paul Szabolcs
Mar 16, 2012·Immunologic Research·Doreen HaaseOlaf Rotzschke
Sep 15, 2007·Journal of Virology·Shuo LiUlf Dittmer
May 18, 2011·International Archives of Allergy and Immunology·Yoshiki YamamotoYasuko Nakano
Jul 12, 2005·The Journal of Clinical Investigation·Danila ValmoriMaha Ayyoub
Oct 3, 2009·Blood·Luis A Verduzco, David G Nathan
Jul 10, 2009·Clinical and Molecular Allergy : CMA·Ngoc P LyJames E Gern
Dec 1, 2007·Genetic Vaccines and Therapy·Ana Cláudia PelizonAlexandrina Sartori
May 23, 2007·Pediatric Research·Cynthia MasalungaElsie S Mainali
Feb 11, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jörn-Hendrik WeitkampD-Brent Polk
May 24, 2014·Journal of Pediatric Surgery·Dhriti MukhopadhyayLena Perger
Mar 12, 2011·Indian Journal of Pediatrics·Alisan YildiranAydan Ikinciogullari
Nov 15, 2006·Clinical and Experimental Immunology·B C HolmUNKNOWN Diabetes Prediction Study in Skåne (DiPiS)
Sep 29, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I E DijkeL J West
Aug 13, 2011·Seminars in Immunology·Manuela Battaglia, Maria-Grazia Roncarolo
Jul 6, 2010·Journal of Theoretical Biology·Irina BaltchevaJean-Yves Le Boudec
Dec 25, 2015·Proceedings. Biological Sciences·A Katharina SimonAndrew McMichael
Sep 7, 2007·Journal of Immunological Methods·Suzanne BresatzSimon C Barry
Aug 11, 2005·Scandinavian Journal of Immunology·K WingA Rudin
Jun 17, 2005·Clinical and Experimental Immunology·A Marchant, M Goldman
Apr 7, 2009·British Journal of Haematology·Kazuhiro NakamuraMasao Kobayashi
Aug 15, 2006·Immunological Reviews·Shimon SakaguchiTakashi Nomura
Oct 18, 2008·Allergy·B SchaubE von Mutius
Jan 17, 2013·Transfusion·Patrice ChevallierBerthe-Marie Imbert-Marcille
Jan 11, 2012·Scandinavian Journal of Immunology·A SvenssonK Eriksson
Oct 27, 2009·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Risa K Benwell, David R Lee
Dec 30, 2009·European Journal of Immunology·Katie L FlanaganSarah Rowland-Jones
Oct 6, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Tatsuya FuchizawaToshio Miyawaki
Oct 3, 2006·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Paula A VelillaClaire A Chougnet
Mar 15, 2016·Nature Reviews. Immunology·Philip J GoulderEllen M Leitman
Mar 7, 2006·Experimental Gerontology·Christian DejacoMichael Schirmer
Apr 20, 2016·Frontiers in Immunology·Hua PanMauricette Michallet

❮ Previous
Next ❯

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