CD27-CD70 interaction: unravelling its implication in normal and neoplastic B-cell growth

Leukemia & Lymphoma
S M LensR H van Oers

Abstract

Members of the Tumour Necrosis Factor-Receptor (TNFR) family play an essential role in the control of lymphoid cell growth and differentiation. The ligand of one of its lymphoid-specific members, CD27, was recently characterized as CD70, a type II transmembrane molecule with homology to TNF that is expressed on activated T and B cells. Ligation of CD27 by its natural ligand generates a potent costimulatory signal for cytokine production and proliferation of activated T cells. In contrast to normal B cells, where CD27 expression is confined to germinal centre cells and to a small subset of circulating B lymphocytes, CD27 expression is found on a large array of distinct B-cell neoplasia. Here, we review recent data on the expression and function of TNFR family members on normal and malignant lymphocytes and propose a role for CD27-CD70 interaction in B-cell development.

References

May 7, 1992·Nature·R J ArmitageC R Maliszewski
Dec 1, 1990·European Journal of Immunology·D MaurerW Knapp
Oct 17, 1991·Nature·J Banchereau, F Rousset
Oct 25, 1991·Proceedings of the National Academy of Sciences of the United States of America·L A TartagliaD V Goeddel
Apr 15, 1991·Biochemical and Biophysical Research Communications·C A SmithR G Goodwin
Jan 1, 1991·Annual Review of Immunology·P L Cohen, R A Eisenberg
Dec 1, 1990·The Journal of Experimental Medicine·H E HeslopM K Brenner
Mar 1, 1993·Journal of Pharmaceutical Sciences·W Piekoszewski, W J Jusko
Jul 1, 1994·Immunology Today·R Q HintzenR A van Lier
Apr 29, 1994·Science·P D CroweC A Smith
Mar 1, 1994·International Immunology·R Q HintzenR A van Lier

❮ Previous
Next ❯

Citations

Sep 19, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kelly BoucherLia E Perez
Oct 6, 2009·Gynecologic Oncology·Sudeepta AggarwalPaul A Moore
Jul 27, 1999·Cytokine·B Erlichman, O M Howard
Apr 3, 2003·British Journal of Haematology·Jeroen E J GuikemaNicolaas A Bos
Dec 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julie A McEarchernChe-Leung Law

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.

B-Cell Lymphoma

B-cell lymphomas include lymphomas that affect B cells. This subtype of cancer accounts for over 80% of non-Hodgkin lymphomas in the US. Here is the latest research.

CNS Lymphoma

In CNS lymphoma, cancerous cells from lymph tissues or other parts of the body form tumors in the brain and/or spinal cord. Here is the latest research on this rare non-Hodgkin lymphoma.