CD28 costimulation is required for the expression of T-cell-dependent cell-mediated immunity against blood-stage Plasmodium chabaudi malaria parasites

Infection and Immunity
Thomas RummelWilliam P Weidanz

Abstract

Mice suppress the parasitemia of acute blood-stage Plasmodium chabaudi malaria by an antibody- or T-cell-dependent cell-mediated mechanism of immunity (AMI and CMI, respectively) or by both mechanisms. To determine whether CD28 costimulation is required for expression of these polar immune responses, we first compared the time courses of P. chabaudi malaria in CD28-deficient (CD28(-/-)) and CD28-intact (CD28(+/+)) mice. Acute infections in both knockout (KO) and control mice followed similar time courses, with the period of descending parasitemia being prolonged approximately 2 weeks in KO mice followed by intermittent low-grade chronic parasitemia. Infected CD28(-/-) mice produced primarily the immunoglobulin M antibody, which upon passive transfer provided partial protection against P. chabaudi challenge, suggesting that the elimination of blood-stage parasites by CD28(-/-) mice was achieved by AMI. To determine whether CD28(-/-) costimulation is required for the expression of CMI against the parasite, we compared the time courses of parasitemia in B-cell-deficient double-KO (J(H)(-/-) x CD28(-/-)) mice and control (J(H)(-/-) x CD28(+/+)) mice. Whereas control mice suppressed parasitemia to subpatent levels within approximate...Continue Reading

References

Feb 1, 1976·Proceedings of the Society for Experimental Biology and Medicine·R G RankA Bondi
Jul 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·P H SchreierD Baltimore
Sep 1, 1994·Immunity·J M GreenC B Thompson
Jun 25, 1993·Science·A W Taylor-RobinsonF Y Liew
Jan 1, 1996·Annual Review of Immunology·D J LenschowJ A Bluestone
Feb 1, 1997·Experimental Parasitology·H C van der HeydeW P Weidanz
Sep 1, 1996·The Journal of Experimental Medicine·D R BrownS L Reiner
Jul 22, 1998·Journal of Immunological Methods·R M MartinA M Lew
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·A M GirvinS D Miller
Jan 5, 2000·Nature·S K YoshinagaG Senaldi
Apr 5, 2000·Journal of Neuropathology and Experimental Neurology·A PratJ P Antel
Apr 4, 2001·The Journal of Clinical Investigation·D A MandelbrotA H Sharpe
Jun 22, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A YamadaM H Sayegh
Nov 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H W MittrückerS H Kaufmann
Feb 8, 2002·Nature·Thomas L Richie, Allan Saul
Jun 13, 2002·Chemical Immunology·Peter Perlmann, Marita Troye-Blomberg
Jul 5, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Eric N VillegasChristopher A Hunter
Nov 22, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel KreiselBruce R Rosengard
Sep 25, 2003·The Journal of Experimental Biology·Siddhartha MahantyLouis H Miller
Oct 15, 2003·Immunology Letters·Francine CigelWilliam P Weidanz
Dec 4, 2003·Nature Reviews. Immunology·Oreste Acuto, Frédérique Michel

❮ Previous
Next ❯

Citations

Jun 14, 2005·Current Opinion in Immunology·Christian R Engwerda, Michael F Good
Aug 4, 2005·PLoS Biology·Renaud LacroixJacob C Koella
Jan 18, 2014·Cytokine & Growth Factor Reviews·Zuoan YiGail A Bishop
Sep 17, 2008·Immunopharmacology and Immunotoxicology·Bettina Panagiota Iliopoulou, Brigitte T Huber
Dec 7, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bettina P IliopoulouBrigitte T Huber
Jan 12, 2019·Frontiers in Immunology·Rebecca FaleiroMichelle Wykes

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.