CD3-specific antibody-induced T-cell apoptosis and apoptotic cell uptake lead to CD3-specific antibody-induced tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

CD3-specific antibody-induced T-cell apoptosis and apoptotic cell uptake lead to CD3-specific antibody-induced tolerance

Abstract

References

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF

TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu

Conversion of peripheral CD4+CD25- naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3

Phosphatidylserine receptor and clearance of apoptotic cells

Anti-CD3 monoclonal antibodies: a new step towards therapy in new-onset type 1 diabetes

One step towards restoration of self-tolerance in human autoimmune diseases

Results of a non-specific immunomodulation therapy in chronic heart failure (ACCLAIM trial): a placebo-controlled randomised trial

A critical function for TGF-beta signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

CD3-specific antibody-induced immune tolerance involves transforming growth factor-beta from phagocytes digesting apoptotic T cells

Apoptosis in the pathogenesis of systemic lupus erythematosus

Towards the use of intravenous apoptotic leukocyte infusion as a cell-based therapy approach?

Citations

Intravenous apoptotic cell infusion as a cell-based therapy toward improving hematopoietic cell transplantation outcome

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