PMID: 11920499Mar 29, 2002Paper

CD3-zetachain expression of intratumoral lymphocytes is closely related to survival in gastric carcinoma patients

Cancer
Sumiya IshigamiTakashi Aikou

Abstract

Impaired or reduced CD3 zeta chain (CD3-zeta) expression in T cells has been identified in various cancers and may be associated with an ineffective immune response. The clinical significance of CD3-zeta chain expression in tumor-infiltrating lymphocytes (TILs) in gastric carcinoma remains unclear. The authors immunohistochemically investigated CD3-zeta expression in TILs in 185 patients who had undergone curative gastrectomy. CD3-zeta/CD3 epsilon (CD3-epsilon) ratios were calculated. Patients were divided into two groups: a normal CD3-zeta group (n = 121) and a reduced CD3-zeta group (n = 64). Patients with a zeta per epsilon ratio of greater than 66% were placed in the normal CD3-zeta group. Patients in the normal CD3-zeta group had fewer lymph node metastasis (P < 0.01) and a shallower depth of invasion (P < 0.05) than those in the reduced CD3-zeta group. The 5-year survival rate was 72% in the normal CD3-zeta group, which was significantly better than that in the reduced CD3-zeta group (55%; P < 0.01). When stratified according to clinical stage, the prognostic value was significantly different only in Stage IV patients. Multivariate analysis showed that CD3-zeta expression was an independent prognostic factor (P = 0.03) ne...Continue Reading

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Citations

Nov 29, 2011·Cancer Immunology, Immunotherapy : CII·Viktor Umansky, Alexandra Sevko
Mar 1, 2012·Cancer Immunology, Immunotherapy : CII·Sumiya IshigamiShoji Natsugoe
Oct 5, 2011·Proceedings of the National Academy of Sciences of the United States of America·Christiane MeyerViktor Umansky
Jan 24, 2009·Familial Cancer·Kristen M DrescherHenry T Lynch
Jul 25, 2008·Journal of Cancer Research and Clinical Oncology·Leticia Llanes-FernándezCristina Rodríguez-Padilla
Apr 19, 2007·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·S-J GuoS-R Zhang
Jul 21, 2004·Gynecologic Oncology·Douglas D TaylorCiçek Gerçel-Taylor
Jan 3, 2006·Gynecologic Oncology·Sibel AkyolDouglas D Taylor
Sep 23, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sandeep KrishnanGeorge C Tsokos
Dec 18, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maarten A LigtenbergRolf Kiessling
Feb 5, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Andrea LadányiJózsef Tímár
Aug 21, 2021·Frontiers in Cell and Developmental Biology·Yue FengYunyan Zhang

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