CD30 and its ligand: possible role in regulation of teratoma stem cells

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
M F PeraD P Cerretti

Abstract

Like the oocyte, the cells of the early embryo, and primordial germ cells, human teratocarcinoma stem cells are pluripotent, capable of giving rise to a wide range of somatic and extraembryonic tissues. Growth factors which regulate the growth of multipotent stem cells in the mouse have been identified, but none of these have been shown conclusively to have similar effects on human or primate multipotent stem cells. CD30 is a member of the tumour necrosis factor receptor superfamily with a restricted pattern of tissue distribution, limited to immune cells, decidual tissue, and human embryonal carcinoma: in common with other embryonal carcinoma markers, CD30 is found in foci of cells in a sub-population of seminomas. CD30 ligand is a transmembrane protein, structurally related to tumour necrosis superfamily members TNF alpha, TNF beta, and CD40. CD30 ligand is expressed by T and B lymphocytes, macrophages, and a variety of normal haematopoietic cells and tumours derived from them, and exerts pleiotropic effects on normal and malignant lymphoid cells, including death, differentiation, or cell division. Studies on cultured cell lines derived from human embryonal carcinomas and yolk sac carcinomas confirm CD30 expression in the for...Continue Reading

References

Oct 1, 1989·Differentiation; Research in Biological Diversity·M F PeraJ M Parrington
Aug 15, 1995·Proceedings of the National Academy of Sciences of the United States of America·J A ThomsonJ P Hearn
Apr 14, 1995·Science·S Artavanis-TsakonasM E Fortini
May 1, 1994·Human Pathology·J A Ferreiro
Jun 1, 1996·British Journal of Haematology·A YounesM Andreeff
Jun 1, 1996·Immunology Letters·S RomagnaniE Maggi
Aug 1, 1996·Biology of Reproduction·J A ThomsonJ P Hearn
Nov 1, 1996·Human Pathology·A HittmairH Feichtinger

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Citations

Apr 15, 2004·European Urology·A M WinstanleyUNKNOWN Eurpean Association of Pathologists, Uropathology Division in Florence
Feb 28, 2006·Nature Biotechnology·Daniella HerszfeldMartin F Pera
May 18, 1999·Current Opinion in Oncology·R T Oliver
Apr 3, 1998·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·D M de Kretser, I Damjanov
Apr 17, 2009·American Journal of Clinical Pathology·Daisuke Nonaka
Jun 3, 2004·Cancer Genetics and Cytogenetics·Finn Edler von Eyben
Mar 18, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·R ChiarleG Inghirami
Jan 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Xavier LeroyBernard Gosselin
Jun 30, 2004·The American Journal of Surgical Pathology·Timothy D JonesLiang Cheng
Feb 13, 2016·Immunological Reviews·Niels W C J van de DonkPaul W H I Parren

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