Abstract
DLBCL is a heterogeneous disease with 40% of patients presenting as refractory/relapsing disease following R-CHOP treatment. Few recent studies investigating CD30 expression in DLBCL reported various prognostic effects. This study aimed to evaluate CD30 expression and its correlation with MYC rearrangement and to clarify its prognostic significance in DLBCL. In 98 patients with de novoDLBCL, we studied CD30 expression by immunohistochemistry using different cutoff values (>0%, ≥20%, and ≥40% lymphoma cells, respectively) and correlated with the corresponding MYC rearrangement status by FISH. The clinicopathologic features were very similar between the CD30+ and CD30- groups. The only major difference was that CD30 expression was nearly exclusively seen in cases without MYC rearrangement. CD30 expression was not predictive of overall survival irrespective of therapy regimens, cell of origin, or MYC rearrangement status (P > 0.05). In the 27 patients receiving aggressive regimens, CD30 expression was associated with better OS (P = 0.008) when all patients were included while the survival advantage was lost (P = 0.21) if MYC rearranged cases were excluded. CD30 expression was not associated with prognosis in our cohort of de novoD...Continue Reading
References
Feb 7, 1992·Cell·H DürkopH Stein
Sep 2, 1982·Nature·U SchwabV Diehl
Aug 6, 2003·Proceedings of the National Academy of Sciences of the United States of America·George WrightLouis M Staudt
Sep 25, 2003·Blood·Christine P HansWing C Chan
Jun 16, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laurie H SehnJoseph M Connors
Nov 16, 2006·Blood·Laurie H SehnJoseph M Connors
Jun 12, 2008·Blood·Lisa M RimszaRandy D Gascoyne
Oct 5, 2010·Haematologica·Laurence de Leval, Philippe Gaulard
Nov 5, 2010·The New England Journal of Medicine·Anas YounesAndres Forero-Torres
Dec 2, 2010·Blood·Sietse M AukemaPhilip M Kluin
Oct 18, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shaoying LiL Jeffrey Medeiros
Jan 26, 2012·Blood·Zijun Y Xu-MonetteKen H Young
Mar 23, 2012·Leukemia·C ViscoK H Young
Apr 19, 2012·Blood·Ajay K GopalJasmine Zain
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara ProAndrei Shustov
Aug 2, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nathalie A JohnsonRandy D Gascoyne
Jan 25, 2013·Blood·Shimin HuKen H Young
Feb 26, 2013·Leukemia & Lymphoma·Germán Campuzano-ZuluagaJennifer R Chapman-Fredricks
Aug 14, 2013·Advances in Anatomic Pathology·Shaoying LiL Jeffrey Medeiros
Aug 12, 2014·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Shaoying LiL Jeffrey Medeiros
Aug 20, 2014·British Journal of Haematology·Graham W SlackRandy D Gascoyne
Jan 13, 2015·Blood·Eric D JacobsenNancy L Bartlett
Apr 2, 2015·The American Journal of Surgical Pathology·Xuan Julia WangShaoying Li
Citations
Jan 26, 2016·Expert Review of Hematology·Muhammad O Jamil, Amitkumar Mehta
Dec 8, 2015·Journal of Hematopathology·J Han van Krieken
Sep 11, 2016·Current Hematologic Malignancy Reports·Geetika BhattBeth Christian
Nov 7, 2016·Human Pathology·Jie XuShaoying Li
May 20, 2017·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Jinjun ChengJohn Kim Choi
Apr 19, 2018·Journal of Clinical Pathology·Qi-Xing GongZhi-Hong Zhang
Sep 14, 2018·The American Journal of Surgical Pathology·Bo-Jung ChenLeticia Quintanilla-Martinez
Aug 5, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Andrés E QuesadaShaoying Li
Oct 1, 2019·The American Journal of Surgical Pathology·Mina L XuAlejandro A Gru
Dec 30, 2016·Annals of Hematology·Saeko OtaJunya Kuroda
May 25, 2021·Yonago Acta Medica·Hermawan IstiadiAwal Prasetyo
Jun 9, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Carla Isabelly Rodrigues-FernandesPablo Agustin Vargas