CD30 expression in neoplastic T cells of follicular T cell lymphoma is a helpful diagnostic tool in the differential diagnosis of Hodgkin lymphoma

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc
Sylvia HartmannMartin-Leo Hansmann

Abstract

Follicular T cell lymphoma is derived from follicular T-helper cells. In many cases, neoplastic T cells form rosettes around Hodgkin-Reed-Sternberg-like cells, which can lead to the misdiagnosis of classical Hodgkin lymphoma. The aim of the present study was to obtain a better understanding of this rosetting phenomenon and to recognize features that are helpful in the differential diagnosis of classical Hodgkin lymphoma. Sixteen mostly elderly follicular T cell lymphoma patients (mean 66 years) were analyzed. Fifteen of the 16 follicular T cell lymphoma cases presented with Hodgkin-Reed-Sternberg-like cells, which were CD20-positive in 27% of the cases and Epstein-Barr virus-infected in nearly all cases. Frequently, the immunophenotype of rosetting neoplastic T cells differed from the bulk neoplastic cells with less numerous T-follicular helper cell markers expressed, suggesting a modulation of T-follicular helper cell marker expression in the neoplastic T cells. In 75% of the cases, variable CD30 expression was encountered in the neoplastic T cells, likely reflecting an activation state in these cells. Hodgkin-Reed-Sternberg-like cells were positive for CCL17, and follicular T cell lymphoma tumor cells expressed its receptor C...Continue Reading

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Citations

Dec 12, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Charles Van SlambrouckGirish Venkataraman
Dec 3, 2020·Diagnostics·Paola ParentePaolo Graziano
Feb 27, 2021·Frontiers in Immunology·Kalliopi IoannidouLaurence de Leval
Jul 16, 2021·Expert Review of Hematology·Kennosuke KarubeKoichi Ohshima
Feb 26, 2019·Annals of Diagnostic Pathology·Dennis P O'MalleyMohamed E Salama

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Methods Mentioned

BETA
biopsy
biopsies

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