CD30 Expression in Pediatric Neoplasms, Study of 585 Cases

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Jinjun ChengJohn Kim Choi

Abstract

CD30 is a member of the tumor necrosis factor receptor superfamily, member 8 (TNFRSF8), and its normal expression is restricted to activated T and B cells. In tumor cells, CD30 expression is most commonly associated with lymphoid malignancies (Hodgkin and non-Hodgkin lymphomas) and is a therapeutic target using anti-CD30 antibody. CD30 expression has been reported also in mostly adult non-lymphoid malignancies, raising the possibility of CD30-targeted therapy for additional tumors. In this study, we examined the incidence of CD30 expression in 251 hematopoietic and 334 non-hematopoietic cases of pediatric tumors. As expected, strong and membranous CD30 staining was seen in anaplastic large cell lymphoma, classical Hodgkin lymphoma, and embryonal carcinoma while variable staining was seen in diffuse large B cell lymphoma. In addition, positive CD30 staining was also seen in cases of neuroblastoma (33 of 56), neoplasm with chondroid differentiation (8 of 25), myeloid neoplasms (11 of 120), hemangioma (2 of 12), and mature teratoma (1 of 11). In neuroblastoma, the CD30 expression was generally restricted to cells with ganglion differentiation; staining of ganglion cells was also seen in the one positive case of mature teratoma. In...Continue Reading

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Citations

Oct 3, 2017·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lia GoreGregory Reaman
Feb 16, 2019·Pediatric Blood & Cancer·Mohammad H Abu ArjaMohamed S AbdelBaki
Oct 1, 2019·The American Journal of Surgical Pathology·Mina L XuAlejandro A Gru

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Methods Mentioned

BETA
flow cytometry

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