CD34-immunoreactive balloon cells in cortical malformations

Acta Neuropathologica
Susanne FauserIngmar Blümcke

Abstract

Balloon cells are histopathological hallmarks of various cortical malformations, i.e., focal cortical dysplasia (Taylor's type, FCD IIb), hemimegalencephaly (HME) or cortical tubers (tuberous sclerosis, TSC). Whether this intriguing cell type results from similar pathogenetic pathways remains to be shown. Here, we analyzed the immunohistochemical distribution pattern of the CD34 epitope in surgical specimens from 34 patients with FCD IIb, compared to that of 6 patients with TSC and 3 patients with HME. In normal brain, CD34 occurs only transiently during neurulation, but cannot be detected in mature neuroectodermal cell progenies. In contrast, 58% of our patients showed CD34 immunoreactivity within a subpopulation of balloon cells. Interestingly, CD34-positive balloon cells were confined to the white matter, but never observed in neocortical layers. Furthermore, balloon cells expressing neurofilament protein were also restricted to white matter, whereas GFAP-positive balloon cells were observed either in white or gray matter location. Clinical characteristics did not significantly differ between patients with CD34-positive versus CD34-negative lesions. No significant correlation was found between CD34 expression and genetic alt...Continue Reading

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Citations

May 7, 2005·Acta Neuropathologica·Chris EnglundRobert F Hevner
Jun 21, 2005·Acta Neuropathologica·Michelle HildebrandtIngmar Blümcke
Apr 23, 2010·Acta Neuropathologica·George HadjivassiliouMaria Thom
Dec 21, 2013·Trends in Neurosciences·Nicola MarchiDamir Janigro
Jan 9, 2008·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Chitose SugiuraKousaku Ohno
Feb 1, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Masaya NagaishiYoichi Nakazato
Mar 9, 2011·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Manami UedaHajime Miyata
Feb 1, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Eleonora Aronica, Peter B Crino
May 8, 2015·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Tadashi KimuraAkiyoshi Kakita
Nov 7, 2007·Journal of Neuropathology and Experimental Neurology·Maria ThomSanjay M Sisodiya
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Nov 13, 2020·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Hajime MiyataTomoyuki Akiyama
Nov 25, 2020·Neurosurgery·Diana L Thomas, Christopher R Pierson

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