CD34-Selected Allogeneic Hematopoietic Stem Cell Transplantation for Patients with Relapsed, High-Risk Multiple Myeloma

Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
Eric SmithGuenther Koehne

Abstract

We report results of a retrospective analysis of 44 patients with relapsed and high-risk multiple myeloma (MM) undergoing allogeneic CD34-selected hematopoietic stem cell transplantation (HSCT) from HLA-compatible donors. Patients had multiply relapsed disease including relapse at <15 months after autologous transplantation and most patients (28 of 44; 65%) also had high-risk cytogenetics. Before transplantation, patients received busulfan (.8 mg/kg × 10 doses), melphalan (70 mg/m(2) × 2 days), fludarabine (25 mg/m(2) × 5 days), and rabbit antithymocyte globulin (2.5 mg/kg × 2 days). Patients with 10/10 HLA- matched donors were treated prophylactically with low doses of donor lymphocyte infusions (.5 to 1 × 10(6) CD3(+)/kg) starting 4 to 6 months after CD34-selected HSCT. Acute (grade II to IV) graft-versus-host disease (GVHD) and transplantation-related mortality at 12 months were 2% and 18%, respectively. Chronic GVHD was not observed in any patient. Overall and progression-free survival at 2 years were 54% and 31%, respectively. By multivariate analyses, the outcomes of CD34-selected HSCT were influenced by presence of extramedullary disease, disease status before CD34-selected HSCT, and age. This study demonstrates notable ...Continue Reading

References

Nov 25, 1998·Bone Marrow Transplantation·J Mehta, S Singhal
Jan 10, 2001·Bone Marrow Transplantation·M SalamaR H Collins
Jan 25, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bart BarlogieJohn C Crowley
Mar 16, 2007·The New England Journal of Medicine·Benedetto BrunoMario Boccadoro
Jan 25, 2008·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Conor D Collins
Jul 10, 2008·Blood·Laura RosiñolUNKNOWN Programa para el Estudio y la Terapéutica de las Hemopatías Malignas y Grupo Español de Mieloma (PETHEMA/GEM)
Jan 13, 2009·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·David H VesoleUNKNOWN ECOG Myeloma and BMT Committees
May 1, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benjamin D SmithThomas A Buchholz
Feb 25, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Yvonne A EfeberaMuzaffar H Qazilbash
Jul 7, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Bo BjörkstrandGösta Gahrton
Oct 4, 2011·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Francesca PatriarcaPaolo Corradini
Jan 11, 2012·American Journal of Hematology·Qaiser BashirMuzaffar H Qazilbash
Mar 8, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ulas D BayraktarEsperanza B Papadopoulos
Dec 9, 2014·The New England Journal of Medicine·A Keith StewartUNKNOWN ASPIRE Investigators

❮ Previous
Next ❯

Citations

Mar 2, 2016·American Journal of Hematology·Natasha KekreCorey S Cutler
Nov 7, 2017·Leukemia & Lymphoma·Arnab GhoshRenier J Brentjens
Jan 5, 2016·Bone Marrow Transplantation·B DhakalP N Hari
Aug 19, 2017·Current Hematologic Malignancy Reports·Mattia D'AgostinoEric L Smith
Jan 13, 2018·Frontiers in Oncology·Ehsan MalekMarcos de Lima
Sep 21, 2018·American Society of Clinical Oncology Educational Book·Adam D Cohen
Nov 23, 2019·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sergio GiraltEdward Stadtmauer
Jul 28, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Alexandra Gomez-ArteagaDavid J Chung
Jun 19, 2018·Best Practice & Research. Clinical Haematology·Sophia DanhofEric L Smith
Apr 22, 2020·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Phaedon ZavrasGenovefa A Papanicolaou
Jun 11, 2021·Current Treatment Options in Oncology·Panayotis Kaloyannidis, John Apostolidis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.