PMID: 7513987May 1, 1994Paper

CD34+ spindle-shaped cells selectively disappear from the skin lesion of scleroderma

Archives of Dermatology
S AibaH Tagami

Abstract

The pathogenesis of scleroderma is still unknown. Recently, it has become possible to identify different subpopulations of dermal spindle-shaped cells using anti-CD34 and anti-factor XIIIa antibodies. To elucidate whether entire populations of dermal fibroblasts or only a subpopulation of cells are involved in the fibrosis of scleroderma, we compared the staining pattern of these antibodies and antiprocollagen antibody in paraffin-embedded skin sections from the lesions of 27 patients with scleroderma and 15 patients with other collagen diseases and from normal skin of 17 subjects. Cryostat sections from both involved and uninvolved skin of four patients with scleroderma were also stained with anti-CD34, anti-factor XIIIa, and anti-proline-4-hydroxylase antibodies. CD34+ cells were few or absent in the lesions of scleroderma, while a number of CD34+ cells were found in the lesions of other collagen diseases and in normal skin. In contrast, large numbers of factor XIIIa-and procollagen-positive cells were noted in the lesions of scleroderma. Even in the study in which cryostat sections were used, CD34+ cells were totally absent from the lesions of scleroderma, while there were numerous proline-4-hydroxylase-positive cells. Furth...Continue Reading

Citations

Mar 11, 2004·The International Journal of Biochemistry & Cell Biology·Timothy E QuanRichard Bucala
Jun 1, 1996·The American Journal of Dermatopathology·D NarvaezA Claudy
Aug 14, 1999·The American Journal of Dermatopathology·J M McNiffC B Carroll
Jan 22, 2002·The American Journal of Dermatopathology·S E CowperP E LeBoit
Aug 3, 2004·The Journal of Clinical Investigation·Stavros GarantziotisDavid A Schwartz
Jul 22, 2008·Current Rheumatology Reports·Richard H Gomer
Dec 8, 2010·Critical Reviews in Eukaryotic Gene Expression·Robert J Pignolo, Eileen M Shore
Dec 21, 2000·The British Journal of Dermatology·T K GilmourS Kossard
Oct 7, 2008·Journal of the American Academy of Dermatology·Elisabeth B M KroftElke M G J de Jong
Apr 17, 2007·The Journal of Investigative Dermatology·Brian M StramerPaul Martin
Mar 8, 2008·European Journal of Radiology·Shawn E CowperMichael Girardi
Jun 13, 2009·Stem Cells·Robin K SudaRobert J Pignolo
Mar 12, 2008·Journal of Cutaneous Pathology·Gulsun ErdagMark R Wick
Mar 1, 2013·Journal of Cellular and Molecular Medicine·Mirko ManettiLidia Ibba-Manneschi
Aug 14, 2009·Journal of Cutaneous Pathology·Ruth WaltersHideko Kamino
Aug 28, 2016·The American Journal of Pathology·Banafsheh NazariJeffrey L Browning
Jun 12, 2018·Journal of the European Academy of Dermatology and Venereology : JEADV·J S LeeS Cho
Mar 30, 2006·Current Rheumatology Reports·Timothy E QuanRichard Bucala
Dec 21, 2000·Current Rheumatology Reports·J Chesney, R Bucala
Jul 4, 2007·Laboratory Investigation; a Journal of Technical Methods and Pathology·Alberto Bellini, Sabrina Mattoli
Apr 9, 2015·Clinical and Translational Medicine·Peter J Wermuth, Sergio A Jimenez
Apr 21, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Susan K MathaiErica L Herzog
Jul 28, 2011·Expert Review of Clinical Immunology·Alicia UsateguiJosé L Pablos
Oct 19, 2011·Current Rheumatology Reports·Theresa T Lu
Dec 14, 2019·The American Journal of Dermatopathology·Lisa J Borretta, Richard I Crawford
May 25, 2002·Journal of Cutaneous Pathology·Robert HarfordHenry Skelton

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.