CD36 as a therapeutic target for endothelial dysfunction in stroke.

Current Pharmaceutical Design
Sunghee Cho

Abstract

Stroke pathology involves multifactorial pro-death responses, including inflammation, oxidative stress, vascular dysfunction, and activation of necrotic and apoptotic pathways. The interruption of a single specific pathway in defined stroke model systems has not been sufficient to address the multifactorial nature of stroke-induced injuries in the human population. CD36 is a class B scavenger receptor that functions in regulating normal physiological and pathological functions. CD36 pathways are activated by several distinct ligands. Convergence of these pathways results in inflammatory responses and endothelial dysfunction, which may be an underlying cause of cardio- and cerebrovascular diseases. The current review describes receptor CD36-ligand interactions relevant to endothelial function and discusses how targeting CD36 may have therapeutic utility in stroke.

Citations

Nov 16, 2013·Biochemistry. Biokhimii︠a︡·T A ShchelkunovaA N Smirnov
Apr 29, 2014·BMC Cardiovascular Disorders·Luz E Ramos-ArellanoIsela Parra-Rojas
Sep 12, 2013·Medical Hypotheses·Theo DiamandisCesar V Borlongan
May 21, 2016·Plastic Surgery International·Yssel Mendoza MaríJorge Berlanga Acosta
Jul 26, 2016·Frontiers in Molecular Biosciences·Shima ShahjoueiRamin Zand
Feb 24, 2016·Scientific Reports·Jun-Jun ChengJian-Dong Jiang
Dec 6, 2017·Journal of Neuroinflammation·Hiramani DhunganaTarja Malm
Nov 1, 2018·Journal of Neuroscience Research·Cui YangYang Xiang
May 15, 2018·Frontiers in Immunology·Lee A Meier, Bryce A Binstadt
Dec 29, 2018·BMC Complementary and Alternative Medicine·Arunwan UdomkasemsabPattaneeya Prangthip
Oct 17, 2019·Molecular Neurobiology·Steven A RobicsekSylvain Doré
Nov 20, 2020·Neuroscience·Ana-Maria DobriMihail Eugen Hinescu
Nov 14, 2020·Cells·Gary A CuthbertShervanthi Homer-Vanniasinkam

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