CD36 deficiency blunts effects of diet on regulatory T cells in murine gonadal adipose tissue and mesenteric lymph nodes

Cellular Immunology
Lotte GeysIlse Scroyen

Abstract

The effect of cluster of differentiation (CD)36 on regulatory T cells (Treg) was investigated in gonadal (GN) adipose tissues and mesenteric lymph nodes (MLN) of wild-type (WT) and CD36 deficient (CD36(-/-)) mice kept on standard fat (SFD, lean) or on high fat diet (HFD, obese). GN adipose tissue mass was smaller, but MLN size larger for obese CD36(-/-) versus obese WT mice. Overall, the reduction of Treg cells in GN adipose tissue and MLN after a HFD is much more prominent in WT than CD36(-/-) mice. Moreover, CD36(-/-) mice may be protected against obesity-related chronic inflammation.

References

Jun 3, 2000·Annual Review of Immunology·E M Shevach
Sep 19, 2001·The Journal of Clinical Investigation·M FebbraioR L Silverstein
Mar 4, 2003·Nature Immunology·Jason D FontenotAlexander Y Rudensky
Oct 7, 2004·International Immunology·Haruhiko YagiShimon Sakaguchi
Jun 27, 2013·Journal of Leukocyte Biology·Carlos ZamoraSílvia Vidal
Oct 25, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Tracey McLaughlinEdgar Engleman
Nov 13, 2014·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R L TraversD Thompson

❮ Previous
Next ❯

Citations

May 1, 2019·Adipocyte·Jacob CouturierDorothy E Lewis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here