CD36 is a co-receptor for hepatitis C virus E1 protein attachment

Scientific Reports
Jun-Jun ChengJian-Dong Jiang

Abstract

The cluster of differentiation 36 (CD36) is a membrane protein related to lipid metabolism. We show that HCV infection in vitro increased CD36 expression in either surface or soluble form. HCV attachment was facilitated through a direct interaction between CD36 and HCV E1 protein, causing enhanced entry and replication. The HCV co-receptor effect of CD36 was independent of that of SR-BI. CD36 monoclonal antibodies neutralized the effect of CD36 and reduced HCV replication. CD36 inhibitor sulfo-N-succinimidyl oleate (SSO), which directly bound CD36 but not SR-BI, significantly interrupted HCV entry, and therefore inhibited HCV replication. SSO's antiviral effect was seen only in HCV but not in other viruses. SSO in combination with known anti-HCV drugs showed additional inhibition against HCV. SSO was considerably safe in mice. Conclusively, CD36 interacts with HCV E1 and might be a co-receptor specific for HCV entry; thus, CD36 could be a potential drug target against HCV.

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Citations

Jan 7, 2017·Journal of Cellular Biochemistry·Jean-Marc ZinggMohsen Meydani
Apr 20, 2017·Current Infectious Disease Reports·Steven W JohnsonBrianne Raccor
Oct 3, 2019·Genes & Development·Florian RambowColin R Goding
Sep 15, 2017·BioMed Research International·Jian-Rui LiZong-Gen Peng
Jun 13, 2018·Frontiers in Immunology·Johnathan D Guest, Brian G Pierce
Jul 5, 2018·Frontiers in Immunology·Yimin TongJin Zhong
Nov 7, 2019·Developmental and Comparative Immunology·Xiao XiangYafeng Qiu
May 25, 2021·Archives of Toxicology·Joost BoeckmansTamara Vanhaecke
Jun 3, 2021·Viruses·Itai YechezkelNetanel Tzarum
Aug 10, 2021·World Journal of Gastroenterology : WJG·Hui-Chun LiShih-Yen Lo

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Methods Mentioned

BETA
transfection
pull
Co-IP
pull down
chips
nuclear magnetic resonance
Protein Assay
surface
biosensor
chip

Software Mentioned

BIAcore T100 Evaluation
Gelpro32

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