CD36-positive B-lymphoblasts Predict Poor Outcome in Children With B-lymphoblastic Leukemia

Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
Joanna G NewtonSunita I Park

Abstract

Objective We observed that pediatric patients with B lymphoblastic leukemia which expressed CD36 at diagnosis seemed to have worse outcome than patients whose blasts did not. Here, we describe the patient, disease characteristics, pathological, molecular, and genetic features and outcomes of patients with CD36+ B-LL compared to patients with CD36- B-LL. Methods We retrospectively reviewed all flow cytometry reports from September 2008 to December 2015 to identify patients diagnosed at our institution with CD36 expression on B lymphoblasts. CD36- control patients were chosen from our leukemia database and matched 2:1 to CD36+ patients for National Cancer Institute (NCI) risk group at diagnosis. We reviewed diagnostic marrow slides for cytoplasmic granules and abstracted clinical data from patient charts. To identify underlying genetic abnormalities, clinical FISH testing and RNA sequencing was performed on 5 of our CD36+ patients, and RNA-seq data from the NIH Therapeutically Applicable Research to Generate Effective Treatments (TARGET) ALL Expansion Phase 2 data set were examined. Results Twenty-five of 366 (6.83%) patients diagnosed at our institution in the study period had CD36+ blasts. With a median follow-up of 5.32 years,...Continue Reading

References

Jun 5, 2007·American Journal of Hematology·Sean D Pitman, Qin Huang
Jan 9, 2009·The New England Journal of Medicine·Charles G MullighanUNKNOWN Children's Oncology Group
Nov 21, 2009·American Journal of Clinical Pathology·Adam C SeegmillerRobert W McKenna
Sep 11, 2014·The New England Journal of Medicine·Kathryn G RobertsCharles G Mullighan

❮ Previous
Next ❯

Citations

Aug 4, 2019·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Yansheng HaoJulie Teruya-Feldstein

❮ Previous
Next ❯

Methods Mentioned

BETA
flow cytometry
fluorescence microscopy
TARGET
RNA-seq

Software Mentioned

Diva
HTSeq
DESeq
TARGET

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.