CD3/TCRE Expression and Immunoregulatory Milieu Induced in a Secondary Intermediate Host by Different Phases of Hydatid Cyst.

Acta Parasitologica
Alya Mashaal, Al-Shaimaa Mohsen Sadek

Abstract

Echinococcosis is a common health problem in the Mediterranean and the Middle East, and manifests without any symptoms, even in the advanced stages. The present study aimed to investigate the cell mediated-immunoregulatory milieu in rats' echinococcosis induced by three different viability status of Echinococcus granulosus especially in the semi-calcareous stage, which can be used as novel biomarkers to monitor disease progression and open the door to a deeper understanding of the pathways that could contribute to complementary echinococcosis therapies. Rat infection with echinococcosis was induced by three different viable statuses of Echinococcus granulosus (G6) camel strain. During the different stages of parasitic infection, blood serum was harvested from rats containing low-, high-, and not viable (not completely transformed to the calcareous status) protoscoleces fluid. The host Th1/Th2 cytokines-mediated immune cell activation, as well as CD3/TCRE immunoregulation, and proliferation responses were investigated; especially in the semi-calcareous stage as this is the first report characterizing this stage. Both IFN-γ and IL-6 levels significantly increased in the infected groups (P < 0.05), in addition, increased positive ...Continue Reading

References

Aug 11, 2000·BMJ : British Medical Journal·A Berger
Dec 13, 2005·Parasitology International·James C Allan, Philip S Craig
Mar 11, 2008·Experimental Parasitology·Alessandra SiracusanoAntonella Teggi
Jan 10, 2009·Annual Review of Immunology·Jennifer E Smith-GarvinMartha S Jordan
Apr 10, 2009·Parasite : Journal De La Société Française De Parasitologie·D Mezioug, C Touil-Boukoffa
Jun 23, 2009·European Cytokine Network·Manel AmriChafia Touil-Boukoffa
Jan 26, 2011·Journal of Intensive Care Medicine·Randeep S JawaMahmoud Kulaylat
Nov 24, 2011·Clinical & Developmental Immunology·Alessandra SiracusanoElena Ortona
Jan 5, 2012·Endocrine, Metabolic & Immune Disorders Drug Targets·Alessandra SiracusanoElena Ortona
Sep 6, 2014·Cold Spring Harbor Perspectives in Biology·Toshio TanakaTadamitsu Kishimoto
Apr 7, 2016·Lung India : Official Organ of Indian Chest Society·Malay SarkarRajesh Chopra
Jan 28, 2017·Scientific Reports·Michiru NishitaYasuhiro Minami
Feb 6, 2017·Frontiers in Immunology·Sasha Silva-Barrios, Simona Stäger
Nov 8, 2017·World Journal of Hepatology·Nikica M GruborYehuda Shoenfeld
May 28, 2020·Frontiers in Immunology·Justin Komguep NonoKlaus Brehm

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