CD4+ and CD8+ T cells can act separately in tumour rejection after immunization with murine pneumotropic virus chimeric Her2/neu virus-like particles.

PloS One
K AndreassonT Dalianis

Abstract

Immunization with murine pneumotropic virus virus-like particles carrying Her2/neu (Her2MPtVLPs) prevents tumour outgrowth in mice when given prophylactically, and therapeutically if combined with the adjuvant CpG. We investigated which components of the immune system are involved in tumour rejection, and whether long-term immunological memory can be obtained. During the effector phase in BALB/c mice, only depletion of CD4+ and CD8+ in combination, with or without NK cells, completely abrogated tumour protection. Depletion of single CD4+, CD8+ or NK cell populations only had minor effects. During the immunization/induction phase, combined depletion of CD4+ and CD8+ cells abolished protection, while depletion of each individual subset had no or negligible effect. When tumour rejection was studied in knock-out mice with a C57Bl/6 background, protection was lost in CD4-/-CD8-/- and CD4-/-, but not in CD8-/- mice. In contrast, when normal C57Bl/6 mice were depleted of different cell types, protection was lost irrespective of whether only CD4+, only CD8+, or CD4+ and CD8+ cells in combination were eradicated. No anti-Her2/neu antibodies were detected but a Her2/neu-specific IFNgamma response was seen. Studies of long-term memory sho...Continue Reading

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Citations

Jul 14, 2012·Immunotherapy·Tina Dalianis
Sep 4, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Erik A TeunissenEnrico Mastrobattista
Jan 17, 2019·Oncotarget·Catherine GérardNatacha Rocks
Aug 21, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gunnveig GrodelandBjarne Bogen
Jan 3, 2019·Biomaterials Science·Suresh Kumar GullaArabinda Chaudhuri
Jul 13, 2021·Taiwanese Journal of Obstetrics & Gynecology·Yi-Pin ChenJ Timothy Qiu

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Methods Mentioned

BETA
flow cytometry

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