CD4-blockade can induce protection from peanut-induced anaphylaxis.

Frontiers in Immunology
Joana DuarteLuis Graca

Abstract

Monoclonal antibodies (mAb) have been shown effective in inducing immune tolerance in a range of animal models of autoimmunity, allergy, and transplantation. We investigated whether CD4-blockade, effective in inducing transplantation tolerance, could prevent systemic immune responses leading to anaphylaxis. We found that treatment with a non-depleting anti-CD4 mAb could prevent peanut-induced anaphylaxis following subsequent systemic exposure to crude peanut extract (CPE). Furthermore, the effect of CD4-blockade did not interfere with overall immune competence, as anti-CD4 treated mice remained fully competent to respond to unrelated antigens. Protection from anaphylaxis correlated with increased frequency of Foxp3⁺ regulatory T cells (Treg), and was abrogated following Treg depletion. Taken together our data suggest that activation of T cells by CPE in presence of CD4-blockade leads to Treg expansion that can prevent peanut-induced anaphylaxis.

Citations

Oct 23, 2013·Immunology and Cell Biology·Marta CaridadeRuy M Ribeiro
Aug 8, 2013·PloS One·Reem KanjarawiDominique Kaiserlian
Oct 12, 2012·Journal of Allergy·Ana Agua-Doce, Luis Graca
Nov 24, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ana Agua-DoceLuis Graca
Jul 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Joana DuarteLuis Graca

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BETA
electrophoresis
FACS

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