CD4+ CCR5+ and CD4+ CCR3+ lymphocyte subset and monocyte apoptosis in patients with acute visceral leishmaniasis

Immunology
Marcella PotestioE Cillari

Abstract

The potential involvement of apoptosis in the pathogenesis of visceral leishmaniasis (VL) was examined by studying spontaneous and Leishmania antigen (LAg)-induced apoptosis using cryopreserved peripheral blood mononuclear cells (PBMC) of Sicilian patients with VL. Results indicate that monocytes and T lymphocytes from acute VL patients show a significantly higher level of apoptosis compared with that observed in healed subjects. The percentage of apoptotic cells was higher in monocytes than in T lymphocytes. T cells involved in programmed cell death (PCD) were mainly of the CD4(+) phenotype. In particular, the T helper 1-type (Th1) subset, as evaluated by chemokine receptor-5 (CCR5) expression, is involved in this process. Cell death in Th1-type uses a CD95-mediated mechanism. Furthermore, Th1-type CCR5(+) cells are prone to cell suicide in an autocrine or paracrine way, as attested by enhanced expression of CD95L in acute VL patients. The reduction in Th1-type cells by apoptosis was confirmed by the decrease in interferon-gamma secretion. In conclusion, apoptosis of monocytes, CD4(+) and CD4(+) CCR5(+) T cells could be involved in the failure of cell mediated immunity that is responsible for severe immune-depression in VL.

References

Dec 1, 1985·The Journal of Clinical Investigation·E M CarvalhoW D Johnson
Jan 28, 1994·Cell·P Marrack, J Kappler
Jul 1, 1993·The Journal of Clinical Investigation·H W GhalibS G Reed
Mar 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·C C BleulC R Mackay
Jun 1, 1997·Immunology Today·S Romagnani
Nov 14, 1997·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·F Y LiewL Proudfoot
Apr 4, 1998·The Journal of Experimental Medicine·F SallustoA Lanzavecchia
Sep 8, 2001·The Journal of Infection·D H Dockrell
Dec 1, 2001·Current Biology : CB·J M de Freitas BalancoM A Barcinski
Oct 23, 2002·Clinical and Experimental Immunology·L EidsmoH Akuffo
Jan 1, 1994·Parasitology Today·L Gradoni, M Gramiccia

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Citations

Oct 3, 2006·Apoptosis : an International Journal on Programmed Cell Death·Piyali MukherjeeAsoke C Ghose
Oct 12, 2010·Clinical Microbiology Reviews·J L N BarrattD Stark
Mar 5, 2009·Future Microbiology·Susanne Nylén, Hannah Akuffo
Aug 11, 2007·Trends in Immunology·Susanne Nylén, David Sacks
Sep 9, 2011·Veterinary Parasitology·Valéria Marçal Felix de LimaGisele Fabrino Machado
Sep 28, 2014·Veterinary Parasitology·Juliana PerossoValéria Marçal Felix de Lima
Nov 5, 2014·Frontiers in Immunology·Pedro CecílioAnabela Cordeiro da Silva
Jun 16, 2016·Frontiers in Immunology·Anne GeigerPhilippe Holzmuller
Apr 6, 2013·Revista Da Sociedade Brasileira De Medicina Tropical·Pradyot Bhattacharya, Nahid Ali
Sep 12, 2008·Immunopharmacology and Immunotoxicology·Landi V C GuillermoMarcela F Lopes
Mar 11, 2016·Clinical and Vaccine Immunology : CVI·Federico Perdomo-CelisCarlos F Narváez
Sep 21, 2007·International Journal of Immunopathology and Pharmacology·P MansuetoE Cillari
Sep 28, 2013·Journal of Leukocyte Biology·Wânia F Pereira-ManfroMarcela F Lopes
Aug 6, 2020·Journal of Clinical Medicine·Timo Albert NeesSébastien Hagmann
Feb 25, 2021·Environmental Science and Pollution Research International·Mona K GalalAhmed M Hussien

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