CD4 cell levels during treatment for tuberculosis (TB) in Ethiopian adults and clinical markers associated with CD4 lymphocytopenia

PloS One
Sten SkogmarPer Björkman

Abstract

The clinical correlations and significance of subnormal CD4 levels in HIV-negative patients with TB are unclear. We have determined CD4 cell levels longitudinally during anti-tuberculosis treatment (ATT) in patients, with and without HIV co-infection, and their associations with clinical variables. Adults diagnosed with TB (maximum duration of ATT for 2 weeks, and with no history of antiretroviral therapy (ART) in HIV-positive subjects) were included consecutively in eight out-patient clinics in Ethiopia. Healthy individuals were recruited for comparison at one of the study health centers. Data on patient characteristics and physical findings were collected by trained nurses following a structured questionnaire at inclusion and on follow-up visits at 2 and 6 months. In parallel, peripheral blood CD4 cell levels were determined. The evolution of CD4 cell levels during ATT was assessed, and the association between clinical characteristics and low CD4 cell levels at baseline was investigated using regression analysis. In total, 1116 TB patients were included (307 HIV-infected). Among 809 HIV-negative patients, 200 (25%) had subnormal CD4 cell counts (<500 cells/mm(3)), with <350 cells/mm(3) in 82 (10%) individuals. CD4 cell levels...Continue Reading

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Citations

May 17, 2015·QJM : Monthly Journal of the Association of Physicians·C A BalkemaC F Koegelenberg
Feb 12, 2017·QJM : Monthly Journal of the Association of Physicians·O M P Jolobe
Apr 9, 2019·International Journal of Immunopathology and Pharmacology·Elisabetta VenturiniLuisa Galli
May 15, 2018·The Journal of International Medical Research·Xuejiao LuoHaiyan Cui
Jul 3, 2020·Research and Reports in Tropical Medicine·Joseph Baruch BalukuWinceslaus Katagira
Oct 25, 2020·The Journal of Arthroplasty·Pradeep B BhosaleShreekar M Arte
Oct 2, 2021·Annals of Neurology·Omar K SiddiqiIgor J Koralnik

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Methods Mentioned

BETA
X-ray
flow cytometry

Software Mentioned

Excel®
SPSS®

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