PMID: 7543788Apr 1, 1995Paper

CD4+ cytolytic T cells can destroy autologous and MHC-matched macrophages but fail to kill intracellular Mycobacterium bovis-BCG

FEMS Immunology and Medical Microbiology
A D PithieD S Kumararatne

Abstract

Mycobacterium bovis-BCG infected macrophages were exposed in vitro to PPD-stimulated T lymphocytes from tuberculin responsive donors or to a panel of mycobacterial-antigen specific CD4+ T cell clones. Both polyclonal and clonal T cells caused considerable antigen-specific lysis of autologous or MHC class II matched macrophages. However, lysis of infected macrophages did not significantly affect the number of viable mycobacteria which were released into the culture media from lysed macrophages. In tuberculosis, CD4+ cytolytic T cells may be primarily involved in tissue destruction and lack a significant role in acquired cellular immunity.

References

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Nov 1, 1981·Reviews of Infectious Diseases·H Hahn, S H Kaufmann
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Citations

Jun 5, 2003·Clinical and Experimental Immunology·S S De La BarreraM del C Sasiain
Nov 11, 2011·American Journal of Respiratory and Critical Care Medicine·Nicole RitzNigel Curtis
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·D H CanadayW H Boom

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