CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with hepatocellular carcinoma

Cellular Immunology
M NakaoK Itoh

Abstract

We investigated T cell immunity against hepatocellular carcinoma (HCC), and showed that both peripheral blood mononuclear cells and tumor-infiltrating lymphocytes incubated with interleukin-2 alone displayed HLA-nonrestricted but hepatic cancer-specific cytotoxicity in a majority of patients with HCC. Namely, they lysed both HCC and cholangiocellular carcinomas in an HLA-nonrestricted manner, but they did not lyse any tumors with the other histological types tested, normal hepatocytes, or the cells transfected with hepatitis C virus or MUC1 gene. These CTL lines and clones were phenotypically CD3+CD4+CD8-. These unique CTL could play important roles in T cell immunity against HCC.

Citations

Jul 20, 2010·Immunotherapy·Richard E BeatsonJoy M Burchell
Mar 23, 2011·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yanhui XuDavid E Kaplan
Sep 10, 2003·International Reviews of Immunology·Markwin P VeldersW Martin Kast
Aug 29, 2018·Frontiers in Immunology·Sam SheppardNadia Guerra
Sep 17, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Akeel AlisaShahriar Behboudi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.